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Evidence found and GRADE certainty

204 questions · 205 findings · 17 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 69 · 33.7%GRADE not reported 9 · 4.4%Very low 29 · 14.1%Low 36 · 17.6%Moderate 50 · 24.4%High 12 · 5.9%

Summary of findings: continuous cycles alternating aztreonam lysine for inhalation with tobramycin for inhalation solution vs continuous cycles alternating placebo with tobramycin

Quality of life: respiratory domain · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen
1 finding from 1 review

Summary of findings: continuous cycles alternating aztreonam lysine for inhalation with tobramycin for inhalation solution vs continuous cycles alternating placebo with tobramycin

Survival · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings: continuous cycles alternating aztreonam lysine for inhalation with tobramycin for inhalation solution vs continuous cycles alternating placebo with tobramycin

Adverse events: any adverse event in the comparative phase · adults and children with cystic fibrosis and a positive microbiological isolate of P aeruginosa from a respiratory tract specimen

Summary of findings: continuous cycles alternating aztreonam lysine… showed no clear difference in adverse events: any adverse event in the comparative phase compared with continuous cycles alternating placebo with tobramycin (low certainty).

1 finding from 1 review

Summary of findings: garlic supplementation vs placebo

FEV1 (% predicted): mean change from baseline · children aged over eight and adults with cystic fibrosis and chronic pulmonary infection with P aeruginosa

Summary of findings: garlic supplementation showed no clear difference in respiratory function change from baseline in % predicted FEV1 compared with placebo (moderate certainty).

1 finding from 1 review