Findings

What do systematic reviews say?

172 questions · 179 findings · 40 reviews · Musculoskeletal

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No studies found 21 · 11.7%GRADE not reported 7 · 3.9%Very low 24 · 13.4%Low 68 · 38%Moderate 45 · 25.1%High 14 · 7.8%

Risedronate 5 mg/day vs placebo

Serious adverse events · pPostmenopausal women at higher risk of fractures1

Risedronate 5 mg/day showed no clear difference in serious adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Risedronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women 2022 · Cochrane Headline outcomes only
RR 1 [0.94, 1.07]
Studies not reported
Moderate

Risedronate 5 mg/day vs placebo

Clinical vertebral fractures · pPostmenopausal women at higher risk of fractures1

1 finding from 1 review

Risedronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Risedronate 5 mg/day vs placebo

Non‐vertebral fractures · pPostmenopausal women at higher risk of fractures1

Risedronate 5 mg/day probably leads to lower non‐vertebral fractures compared with placebo (moderate certainty).

1 finding from 1 review

Risedronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women 2022 · Cochrane Headline outcomes only
RR 0.8 [0.72, 0.9]
Studies not reported
Moderate

Risedronate 5 mg/day vs placebo

Hip Fracture · pPostmenopausal women at higher risk of fractures1

Risedronate 5 mg/day may leads to lower hip fractures compared with placebo (low certainty).

1 finding from 1 review

Risedronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women 2022 · Cochrane Headline outcomes only
RR 0.73 [0.56, 0.94]
Studies not reported
Low

Intervention not reported

Pain (at study completion) WOMAC (VAS or NRS) from 0 to 20; lower scores mean reduced pain · People with hip or knee osteoarthritis

1 finding from 1 review

High‐intensity versus low‐intensity physical activity or exercise in people with hip or knee osteoarthritis 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 313 participants
Low

Intervention not reported

Physical function (at study completion) WOMAC (self administered health status measure) from 0 to 68; lower scores mean better function · People with hip or knee osteoarthritis

1 finding from 1 review

High‐intensity versus low‐intensity physical activity or exercise in people with hip or knee osteoarthritis 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 310 participants
Low

Intervention not reported

Adverse effects (related to the exercise programs) · People with hip or knee osteoarthritis

It is very uncertain whether the intervention changes adverse effects (related to the exercise programs) (very low certainty).

1 finding from 1 review

High‐intensity versus low‐intensity physical activity or exercise in people with hip or knee osteoarthritis 2015 · Cochrane Headline outcomes only
Peto OR 1.72 [0.51, 5.81]
4 studies · 364 participants
Very low

Intervention not reported

Severe adverse events or withdrawals (due to adverse events) ‐ not reported · People with hip or knee osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

High‐intensity versus low‐intensity physical activity or exercise in people with hip or knee osteoarthritis 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Subgroup analysis: Exercise duration vs resistance

Pain ‐ duration exercise WOMAC (VAS or Likert) from 0 to 20 · Patients with osteoarthritis of the knee or hip

1 finding from 1 review

High‐intensity versus low‐intensity physical activity or exercise in people with hip or knee osteoarthritis 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 200 participants
Very low

Subgroup analysis: Exercise duration vs resistance

Pain ‐ resistance exercise WOMAC (VAS or Likert) from 0 to 20 · Patients with osteoarthritis of the knee or hip

1 finding from 1 review

High‐intensity versus low‐intensity physical activity or exercise in people with hip or knee osteoarthritis 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 113 participants
Very low

Subgroup analysis: Exercise duration vs resistance

Function ‐ duration exercise WOMAC from 0 to 68 · Patients with osteoarthritis of the knee or hip

1 finding from 1 review

High‐intensity versus low‐intensity physical activity or exercise in people with hip or knee osteoarthritis 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 200 participants
Very low

Subgroup analysis: Exercise duration vs resistance

Function ‐ resistance exercise WOMAC from 0 to 68 · Patients with osteoarthritis of the knee or hip

1 finding from 1 review

High‐intensity versus low‐intensity physical activity or exercise in people with hip or knee osteoarthritis 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 113 participants
Low