Findings

What do systematic reviews say?

3,372 questions · 3,874 findings · 666 reviews

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No studies found 431 · 11.1%GRADE not reported 783 · 20.2%Very low 995 · 25.7%Low 909 · 23.5%Moderate 596 · 15.4%High 160 · 4.1%

Summary of findings: Low sodium intake vs high sodium intake

HDL‐cholesterol · Participants with normal or elevated blood pressure, but otherwise healthy

1 finding from 1 review

Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol,… 2020 · Cochrane Headline outcomes only
no estimate extracted
20 studies · 738 participants
High

Spironolactone vs placebo

Risk of high altitude pulmonary oedema · participants at risk of high altitude illness

1 finding from 1 review

Interventions for preventing high altitude illness: Part 2. Less commonly‐used drugs 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 193 participants
Low

Spironolactone vs placebo

Risk of high altitude cerebral oedema · participants at risk of high altitude illness

1 finding from 1 review

Interventions for preventing high altitude illness: Part 2. Less commonly‐used drugs 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 193 participants
Low

Acetazolamide vs spironolactone 100 mg

Risk of high altitude pulmonary oedema · participants at risk of high altitude illness

1 finding from 1 review

Interventions for preventing high altitude illness: Part 2. Less commonly‐used drugs 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 232 participants
Low

Acetazolamide vs spironolactone 100 mg

Risk of high altitude cerebral oedema · participants at risk of high altitude illness

1 finding from 1 review

Interventions for preventing high altitude illness: Part 2. Less commonly‐used drugs 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 232 participants
Low

Sumatriptan vs placebo

Risk of high altitude pulmonary oedema · participants at risk of high altitude illness

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing high altitude illness: Part 2. Less commonly‐used drugs 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Sumatriptan vs placebo

Risk of high altitude cerebral oedema · participants at risk of high altitude illness

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing high altitude illness: Part 2. Less commonly‐used drugs 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Magnesium citrate vs placebo

Risk of high altitude pulmonary oedema · participants at risk of high altitude illness

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing high altitude illness: Part 2. Less commonly‐used drugs 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Magnesium citrate vs placebo

Risk of high altitude cerebral oedema · participants at risk of high altitude illness

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing high altitude illness: Part 2. Less commonly‐used drugs 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Dexamethasone vs placebo

Incidence of high altitude pulmonary oedema (HAPE)‐ not reported · participants at risk of high altitude illness

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing high altitude illness: Part 1. Commonly‐used classes of drugs 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Dexamethasone vs placebo

Incidence of high altitude cerebral oedema (HACE) ‐ not reported · participants at risk of high altitude illness

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing high altitude illness: Part 1. Commonly‐used classes of drugs 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Acetazolamide vs placebo

Risk of high altitude pulmonary oedema · participants at risk of high altitude illness

1 finding from 1 review

Interventions for preventing high altitude illness: Part 1. Commonly‐used classes of drugs 2017 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 1138 participants
Moderate

Acetazolamide vs placebo

Incidence of high altitude cerebral oedema (HACE) ‐ not reported · participants at risk of high altitude illness

Acetazolamide showed no clear difference in incidence of high altitude cerebral oedema (HACE)‐ Follow‐ up: From… compared with placebo (moderate certainty).

1 finding from 1 review

Interventions for preventing high altitude illness: Part 1. Commonly‐used classes of drugs 2017 · Cochrane Headline outcomes only
RR 0.32 [0.01, 7.48]
6 studies · 1126 participants
Moderate

Budesonide vs placebo

Incidence of high altitude pulmonary oedema (HAPE)‐ not reported · participants at risk of high altitude illness

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing high altitude illness: Part 1. Commonly‐used classes of drugs 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Budesonide vs placebo

Incidence of high altitude cerebral oedema (HACE) ‐ not reported · participants at risk of high altitude illness

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for preventing high altitude illness: Part 1. Commonly‐used classes of drugs 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

High protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

Rate of weight gain (g/kg/day) · formula‐fed low birth weight infants

1 finding from 1 review

Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 114 participants
Low

High protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

Linear growth (cm/week) · formula‐fed low birth weight infants

1 finding from 1 review

Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 48 participants
Low

High protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

Growth: head circumference (cm/week) · formula‐fed low birth weight infants

1 finding from 1 review

Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 18 participants
Very low

High protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

IQ score and Bayley score at 18 months or later · formula‐fed low birth weight infants

The review found no eligible studies for this question.

1 finding from 1 review

Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

High protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

Necrotising enterocolitis · formula‐fed low birth weight infants

1 finding from 1 review

Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 46 participants
Low