Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

238 questions · 623 findings · 27 reviews · Dental caries

No studies found 7 · 1.1%GRADE not reported 568 · 91.2%Very low 25 · 4%Low 13 · 2.1%Moderate 10 · 1.6%High 0 · 0%

Gastroesophageal or laryngopharyngeal reflux (GERD/LPR) vs Healthy controls

Oral/pharyngeal microbiota modifications · Adults with gastroesophageal reflux disease (GERD) or laryngopharyngeal reflux (LPR)

No eligible studies investigated reflux-related modifications of the oral or pharyngeal microbiota; this is an evidence gap identified by the review.

1 finding from 1 review

T allele of AMELX rs2106416 vs C allele of AMELX rs2106416

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between T allele vs C allele of AMELX rs2106416 and dental caries susceptibility (T vs C model: OR 0.59, 95% CI 0.16-2.11); certainty not graded.

3 findings from 1 review

GERD vs Healthy individuals without reflux (controls)

Dental caries · Adults with gastroesophageal reflux disease (GERD) or laryngopharyngeal reflux (LPR)

Reflux appears associated with a higher prevalence of dental caries than in healthy individuals based on three studies, though to a lesser extent than erosion; evidence is ungraded and not pooled.

1 finding from 1 review

CT genotype of ENAM rs3796703 vs CC genotype of ENAM rs3796703

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between CT genotype vs CC genotype of ENAM rs3796703 and dental caries susceptibility (CT vs CC model: OR 0.89, 95% CI 0.23-3.48) in the Ethnicity: Asian subgroup; certainty not graded.

3 findings from 1 review

TT genotype of ENAM rs3796703 vs CC genotype of ENAM rs3796703

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between TT genotype vs CC genotype of ENAM rs3796703 and dental caries susceptibility (TT vs CC model: OR 5.22, 95% CI 0.25-108.96) in the Ethnicity: Asian subgroup; certainty not graded.

3 findings from 1 review

CT + TT genotype (T-allele carriers) of ENAM rs3796703 vs CC genotype of ENAM rs3796703

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between CT + TT genotype (T-allele carriers) vs CC genotype of ENAM rs3796703 and dental caries susceptibility (CT + TT vs CC model: OR 0.90, 95% CI 0.23-3.63); certainty not graded.

3 findings from 1 review

TT genotype of AMELX rs6639060 vs CC + CT genotype of AMELX rs6639060

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between TT genotype vs CC + CT genotype of AMELX rs6639060 and dental caries susceptibility (TT vs CC + CT model: OR 1.00, 95% CI 0.42-2.39) in the Ethnicity: Caucasian subgroup; certainty not graded.

3 findings from 1 review