Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,454 questions · 3,562 findings · 816 reviews · Headline outcomes only

No studies found 538 · 15.1%GRADE not reported 239 · 6.7%Very low 933 · 26.2%Low 1,041 · 29.2%Moderate 612 · 17.2%High 199 · 5.6%

100 mg olorinab 3 times/day vs 25 mg olorinab 3 times/day

At least 30% reduction in pain · people with Crohn's disease

It is very uncertain whether 100 mg olorinab 3 times/day changes pain intensity (30% reduction in weekly AAPS) compared with 25 mg olorinab 3 times/day (very low certainty).

1 finding from 1 review

Short duration (3 to 4 days) vs long duration (7 to 14 days) IV therapy

Persistent renal damage at 3 to 6 months: all included children with acute pyelonephritis · children with acute pyelonephritis

Short duration (3 to 4 days) showed no clear difference in persistent renal damage at 3 to 6 months: all included children with… compared with long duration (7 to 14 days) IV therapy (moderate certainty).

1 finding from 1 review

Short duration (3 to 4 days) vs long duration (7 to 14 days) IV therapy

Persistent renal damage at 3 to 6 months: children with initial renal parenchymal damage on initial DMSA scan · children with acute pyelonephritis

Short duration (3 to 4 days) showed no clear difference in persistent renal damage at 3 to 6 months: children with initial… compared with long duration (7 to 14 days) IV therapy (moderate certainty).

1 finding from 1 review