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What do systematic reviews say?

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Evidence found and GRADE certainty

864 questions · 895 findings · 140 reviews · Headline outcomes only

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No studies found 202 · 22.6%GRADE not reported 53 · 5.9%Very low 227 · 25.4%Low 254 · 28.4%Moderate 131 · 14.6%High 28 · 3.1%

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

Mortality before hospital discharge · adults (aged greater than 18 years) with acute heart failure

Summary of findings table ‐ Continuous infusion of intravenous loop… showed no clear difference in all‐cause mortality (from admission to discharge) compared with bolus injection of intravenous loop diuretics (low certainty).

1 finding from 1 review

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

Hospital readmission · adults (aged greater than 18 years) with acute heart failure

Summary of findings table ‐ Continuous infusion of intravenous loop… showed no clear difference in readmission to hospital following discharge compared with bolus injection of intravenous loop diuretics (low certainty).

1 finding from 1 review

Summary of findings table ‐ Continuous infusion of intravenous loop diuretics vs bolus injection of intravenous loop diuretics

Acute kidney injury · adults (aged greater than 18 years) with acute heart failure

Summary of findings table ‐ Continuous infusion of intravenous loop… showed no clear difference in acute kidney injury (adverse event) (from admission to discharge) compared with bolus injection of intravenous loop diuretics (low certainty).

1 finding from 1 review

Continuous platinum infusion vs bolus platinum infusion

Hearing loss · children with cancer treated with platinum‐based therapy

Continuous platinum infusion showed no clear difference in hearing loss (asymptomatic and symptomatic disease according to… compared with bolus platinum infusion (low certainty).

1 finding from 1 review

Continuous platinum infusion vs bolus platinum infusion

Adverse effects: toxic death (no definition provided) · children with cancer treated with platinum‐based therapy

Continuous platinum infusion showed no clear difference in adverse effects: toxic death (no definition provided) compared with bolus platinum infusion (low certainty).

1 finding from 1 review

Continuous glucose monitoring system vs intermittent glucose monitoring

Hypertensive disorders of pregnancy · women with pre‐existing diabetes

Continuous glucose monitoring may leads to lower hypertensive disorders of pregnancy (including pre‐eclampsia,… compared with intermittent glucose monitoring (low certainty).

1 finding from 1 review

Continuous glucose monitoring system vs intermittent glucose monitoring

Perinatal mortality · women with pre‐existing diabetes

Continuous glucose monitoring showed no clear difference in perinatal mortality (stillbirth and neonatal mortality) compared with intermittent glucose monitoring (low certainty).

1 finding from 1 review