Clinical remission1 · Patients with active Crohn's disease
Azathioprine or 6‐mercaptopurine showed no clear difference in clinical remission1 compared with methotrexate (low certainty).
1 finding from 1 review
Clinical remission or improvement · Patients with active Crohn's disease
Azathioprine or 6‐mercaptopurine showed no clear difference in clinical remission or improvement compared with placebo (moderate certainty).
1 finding from 1 review
Adverse events · Patients with active Crohn's disease
Azathioprine or 6‐mercaptopurine may leads to lower adverse events compared with methotrexate (low certainty).
1 finding from 1 review
Withdrawals due to adverse events · Patients with active Crohn's disease
It is very uncertain whether azathioprine or 6‐mercaptopurine changes withdrawals due to adverse events compared with methotrexate (very low certainty).
1 finding from 1 review
Clinical remission · Patients with active Crohn's disease
It is very uncertain whether azathioprine or 6‐mercaptopurine changes clinical remission compared with 5‐ASA or Sulfasalzine (very low certainty).
1 finding from 1 review
Withdrawals due to adverse events · Patients with active Crohn's disease
Azathioprine or 6‐mercaptopurine showed no clear difference in withdrawals due to adverse events compared with 5‐ASA or Sulfasalzine (low certainty).
1 finding from 1 review
Fistula improvement or healing · Patients with active Crohn's disease
Azathioprine or 6‐mercaptopurine showed no clear difference in fistula improvement or healing compared with placebo (low certainty).
1 finding from 1 review
Steroid sparing effect · Patients with active Crohn's disease
Azathioprine or 6‐mercaptopurine probably leads to higher steroid sparing effect compared with placebo (moderate certainty).
1 finding from 1 review
Withdrawals due to adverse events · Patients with active Crohn's disease
Azathioprine or 6‐mercaptopurine showed no clear difference in withdrawals due to adverse events compared with placebo (moderate certainty).
1 finding from 1 review
Serious adverse events · Patients with active Crohn's disease
Azathioprine or 6‐mercaptopurine showed no clear difference in serious Adverse events compared with placebo (low certainty).
1 finding from 1 review
Clinical remission · Patients with active Crohn's disease
Azathioprine probably leads to lower clinical remission compared with infliximab (moderate certainty).
1 finding from 1 review
Clinical remission off steroids · Patients with active Crohn's disease
Azathioprine probably leads to lower clinical remission off steroids compared with infliximab (moderate certainty).
1 finding from 1 review
Mucosal healing · Patients with active Crohn's disease
Azathioprine probably leads to lower mucosal healing compared with infliximab (moderate certainty).
1 finding from 1 review
Intervention not reported
Induction of remission at 4 weeks · Childen (<16 years old)with active Crohn's disease
The intervention showed no clear difference in induction of remission at 4 weeks (low certainty).
1 finding from 1 review
Severity of PTSD symptoms · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
1 finding from 1 review
Drug or alcohol use, or both following treatment completion ‐ Individual‐based intervention · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
1 finding from 1 review
Treatment completers · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
It is very uncertain whether non‐trauma‐focused psychological intervention for PTSD and SUD or… changes treatment completers compared with active psychological intervention (very low certainty).
1 finding from 1 review
Severity of PTSD symptoms · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
1 finding from 1 review
Drug or alcohol use, or both following treatment completion ‐ Individual‐based intervention · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
1 finding from 1 review
Treatment completers · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
Trauma‐focused psychological intervention showed no clear difference in treatment completers compared with active psychological intervention (low certainty).
1 finding from 1 review