Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,584 questions · 3,695 findings · 567 reviews

No studies found 784 · 21.2%GRADE not reported 308 · 8.3%Very low 1,036 · 28%Low 971 · 26.3%Moderate 440 · 11.9%High 156 · 4.2%

Continuous vs intermittent bolus (nasogastric and orogastric tube) milk feeding ‐ all preterm infants less than 1500 grams

Necrotising enterocolitis · preterm infants less than 1500 grams

Continuous showed no clear difference in necrotising enterocolitis (NEC) compared with intermittent bolus (nasogastric and orogastric tube) milk feeding ‐… (low certainty).

1 finding from 1 review

Antioxidants vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults with trichotillomania

Antioxidants showed no clear difference in treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (low certainty).

1 finding from 1 review

Cell signal transducers vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults with trichotillomania

Cell signal transducers showed no clear difference in treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (low certainty).

1 finding from 1 review

Glutamate modulators vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults with trichotillomania

Glutamate modulators probably leads to higher treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (moderate certainty).

1 finding from 1 review

Glutamate modulators vs placebo

Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · children and adolescents with trichotillomania

Glutamate modulators showed no clear difference in treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (low certainty).

1 finding from 1 review

Glutamate modulators vs placebo

Dropouts due to adverse events · children and adolescents with trichotillomania

Glutamate modulators showed no clear difference in tolerability of treatment ‐ dropouts due to adverse eventscDropout… compared with placebo (low certainty).

1 finding from 1 review

Antioxidants vs placebo

Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · adults with trichotillomania
1 finding from 1 review