Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,751 questions · 12,775 findings · 807 reviews · Headline outcomes only

No studies found 3,413 · 26.7%GRADE not reported 709 · 5.5%Very low 3,483 · 27.3%Low 3,165 · 24.8%Moderate 1,628 · 12.7%High 377 · 3%

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Medical/surgical masks vs no masks

Viral respiratory illness ‐ laboratory‐confirmed influenza/SARS‐CoV‐2 · general population

Medical/surgical masks showed no clear difference in viral respiratory illness ‐ laboratory‐confirmed influenza/SARS‐CoV‐2 compared with no masks (moderate certainty).

1 finding from 1 review

N95 respirators vs medical/surgical masks

Viral respiratory illness ‐ laboratory‐confirmed influenza · general population and healthcare workers

N95 respirators showed no clear difference in viral respiratory illness ‐ laboratory‐confirmed influenza compared with medical/surgical masks (moderate certainty).

1 finding from 1 review

High vs low dose pegylated interferon alpha‐2a or alpha‐2b

PEG interferon alpha‐2a · patients on HD with HCV infection

High showed no clear difference in PEG interferon alpha‐2a compared with low dose pegylated interferon alpha‐2a or alpha‐2b (low certainty).

4 findings from 1 review
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High vs low dose pegylated interferon alpha‐2a or alpha‐2b

PEG interferon (alpha‐2b) · patients on HD with HCV infection

High showed no clear difference in PEG interferon alpha‐2b compared with low dose pegylated interferon alpha‐2a or alpha‐2b (low certainty).

2 findings from 1 review

High vs low dose pegylated interferon alpha‐2a or alpha‐2b

PEG interferon (combined) · patients on HD with HCV infection

High showed no clear difference in PEG interferon (combined) compared with low dose pegylated interferon alpha‐2a or alpha‐2b (moderate certainty).

3 findings from 1 review