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Evidence found and GRADE certainty

1,835 questions · 1,886 findings · 74 reviews · Skin

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No studies found 542 · 28.7%GRADE not reported 130 · 6.9%Very low 326 · 17.3%Low 434 · 23%Moderate 348 · 18.5%High 106 · 5.6%

Terbinafine 1% cream/gel vs Placebo (vehicle cream)

Adverse effects Reported by investigators 'and' or 'or' participants · patients with tinea cruris and tinea corporis

It is very uncertain whether terbinafine 1% cream/gel changes adverse effects Reported by investigators 'and' or 'or' participants compared with placebo cream/gel (very low certainty).

1 finding from 1 review

Azoles vs placebo

Adverse effects Reported by investigators 'and' or 'or' participants · patients with tinea cruris and tinea corporis

It is very uncertain whether azoles changes adverse effects Reported by investigators 'and' or 'or' participants compared with placebo (very low certainty).

1 finding from 1 review

Terbinafine 1% cream/gel vs Placebo (vehicle cream)

Participant‐judged cure Judgement of treatment as 'good' or 'very good' · patients with tinea cruris and tinea corporis

Terbinafine 1% cream/gel may leads to higher participant‐judged cure Judgement of treatment as 'good' or 'very… compared with placebo cream/gel (low certainty).

1 finding from 1 review

Naftifine 1% cream once or twice daily vs placebo cream once or twice daily

Mycological cure · patients with tinea cruris and tinea corporis

Naftifine 1% cream once or twice daily may leads to higher mycological cure Negative KOH microscopy and culture. Treatment… compared with placebo cream once or twice daily (low certainty).

1 finding from 1 review

Naftifine 1% cream once or twice daily vs placebo cream once or twice daily

Clinical cure · patients with tinea cruris and tinea corporis

Naftifine 1% cream once or twice daily may leads to higher clinical cure Resolution of clinical signs and symptoms at least 2… compared with placebo cream once or twice daily (low certainty).

1 finding from 1 review

Naftifine 1% cream once or twice daily vs placebo cream once or twice daily

Adverse effects Reported by investigators 'and' or 'or' participants · patients with tinea cruris and tinea corporis

It is very uncertain whether naftifine 1% cream once or twice daily changes adverse effects Reported by investigators 'and' or 'or' participants compared with placebo cream once or twice daily (very low certainty).

1 finding from 1 review

Imiquimod 5% cream with tazarotene 0.1% gel vs Imiquimod 5% cream alone

Primary outcome: Histological complete response ( available‐case analysis) No residual LM in staged excision 2 months post‐treatment · participants with melanoma in situ, including lentigo maligna

Imiquimod 5% cream with tazarotene 0.1% gel showed no clear difference in primary outcome: Histological complete response (intention‐to‐treat)… compared with imiquimod 5% cream alone (low certainty).

2 findings from 1 review

Imiquimod 5% cream with tazarotene 0.1% gel vs Imiquimod 5% cream alone

Discontinuation of treatment due to side effects ( · participants with melanoma in situ, including lentigo maligna

Imiquimod 5% cream with tazarotene 0.1% gel showed no clear difference in secondary outcome: Discontinuation of treatment because of harms… compared with imiquimod 5% cream alone (low certainty).

1 finding from 1 review

Imiquimod 5% cream with tazarotene 0.1% gel vs Imiquimod 5% cream alone

Secondary outcome: Inflammatory response (number of lesions with grade 2 or 3) Grade 2 or 3 Inflammation² · participants with melanoma in situ, including lentigo maligna

Imiquimod 5% cream with tazarotene 0.1% gel may leads to higher secondary outcome: Inflammatory response (number of lesions with… compared with imiquimod 5% cream alone (low certainty).

1 finding from 1 review

Chinese herbal medicines vs placebo

Total effectiveness rate (Analysis 1.1) Clinician's rating · atopic eczema

CHM may leads to higher total effectiveness rate (Analysis 1.1) Clinician's rating compared with placebo (low certainty).

1 finding from 1 review