Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,801 questions · 4,079 findings · 473 reviews

No studies found 669 · 16.4%GRADE not reported 852 · 20.9%Very low 738 · 18.1%Low 903 · 22.1%Moderate 716 · 17.6%High 201 · 4.9%

Self‐management interventions vs usual care

Courses of oral corticosteroids · patients with chronic obstructive pulmonary disease

Self‐management interventions including action plans for exacerbations showed no clear difference in courses of oral steroids compared with usual care (low certainty).

1 finding from 1 review

Umeclidinium bromide vs placebo

Exacerbations requiring steroids or antibiotics or both: number of participants · patients with chronic obstructive pulmonary disease

Umeclidinium bromide leads to lower number of participants with exacerbations requiring steroids,… compared with placebo (high certainty).

1 finding from 1 review

Umeclidinium bromide vs placebo

Quality of life: number of participants with clinically significant improvement (≥ 4 units) in SGRQ total score · patients with chronic obstructive pulmonary disease

Umeclidinium bromide probably leads to higher quality of life: number of participants with ≥ 4 units improvement… compared with placebo (moderate certainty).

1 finding from 1 review

Umeclidinium bromide vs placebo

Improvement in symptoms: number of participants with clinically significant improvement: using TDI focal score (≥ 1 unit) · patients with chronic obstructive pulmonary disease

Umeclidinium bromide leads to higher number of participants with ≥ 1 unit improvement in TDI focal score compared with placebo (high certainty).

1 finding from 1 review

Umeclidinium bromide vs placebo

Adverse events (not including serious adverse events): number of participants · patients with chronic obstructive pulmonary disease

Umeclidinium bromide showed no clear difference in adverse events (not including serious adverse events) compared with placebo (moderate certainty).

1 finding from 1 review