Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,954 questions · 2,335 findings · 149 reviews · Oral Health

No studies found 436 · 18.7%GRADE not reported 1,370 · 58.7%Very low 254 · 10.9%Low 173 · 7.4%Moderate 80 · 3.4%High 22 · 0.9%

Naproxen vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral naproxen (NSAID) led to lower pain intensity (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral diclofenac sodium (NSAID) vs placebo

Tenderness on palpation of three or more masticatory muscles · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral diclofenac sodium (NSAID) showed no clear difference in tenderness on palpation of three or more masticatory muscles compared with placebo; GRADE not reported.

1 finding from 1 review

Oral glucosamine hydrochloride/chondroitin sulphate vs placebo

Withdrawals due to adverse events · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Naproxen vs placebo

Adverse events (reported; mild, no withdrawals) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Oral celecoxib (COX-2 inhibitor) vs placebo

Adverse events (reported; mild, no withdrawals) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Oral clonazepam (benzodiazepine) vs placebo

Withdrawals due to adverse events · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Oral glucosamine hydrochloride/chondroitin sulphate vs placebo

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral glucosamine hydrochloride/chondroitin sulphate showed no clear difference in pain intensity (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral diclofenac sodium (NSAID) vs placebo

Severe or very severe symptoms · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral diclofenac sodium (NSAID) showed no clear difference in severe or very severe symptoms compared with placebo; GRADE not reported.

1 finding from 1 review

Summary of findings table ‐ Topical capsaicin vs placebo

Present pain of TMD (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Topical capsaicin (0.025% cream) showed no clear difference in present pain of TMD (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Oral diazepam vs placebo

Number of participants with severe dysfunction (pain of TMD not improved) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral diazepam (benzodiazepine) showed no clear difference in number of participants with severe dysfunction (pain of TMD not… compared with placebo; GRADE not reported.

1 finding from 1 review

Hypnosis vs No hypnosis (no hypnotic intervention)

Measures of behaviour during local anaesthesia administration (undesirable behaviours: crying, hand movement, physical resistance, leg movement) · Children aged 4 to 13 years with no previous dental experience undergoing restorative treatment with local anaesthesia (Gokli 1994)
1 finding from 1 review
  • Patients who were hypnotised demonstrated fewer undesirable behaviours (crying, hand movement, physical resistance and leg movement) than those who did not undergo hypnosis. Decreased crying with hypnosis was the only…
    1 study · 29 participants
    GRADE not reported

Hypnosis vs Inhalation sedation with nitrous oxide and oxygen

Measures of behaviour / negative responses during local anaesthesia administration · Children aged 10 to 16 years undergoing orthodontic extractions (Braithwaite 2005)
1 finding from 1 review
  • Hypnosis can control some of the patient's negative responses to dental treatment, such as movement and behaviour, during administration of local anaesthesia. (Braithwaite 2005; single-blind cross-over, 10 patients…
    1 study · 10 participants
    GRADE not reported

Piroxicam vs placebo

Adverse events (reported; mild, no withdrawals) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Oral prazepam (benzodiazepine) vs placebo

Adverse events (reported; mild, no withdrawals) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…
1 finding from 1 review

Orthodontic treatment with appliances inducing stable, permanent orthodontic tooth movement (splints worn 8 to 12 weeks and surgical interventions excluded) vs Control: no treatment, placebo, or reassurance

Overall symptoms, pain and headache (relief from symptoms assessed by global measures) · Adults aged 18 years or older with clinically diagnosed TMD (exhibiting two or more of the listed signs and/or symptoms)

The review found no eligible studies for this question.

1 finding from 1 review

Hypnosis vs No hypnosis (no hypnotic intervention)

Orthodontic appliance (headgear) wearing time and patient co-operation · Children (mean age approximately 10 years) with skeletal Class II division 1 malocclusion undergoing orthodontic treatment with cervical…
1 finding from 1 review
  • Hypnosis for children undergoing dental treatment 2010 · Cochrane All outcomes
    6 months
    A statistically significant decrease (P < 0.05) in headgear wear was observed in the control (verbal motivation) group from the first to the sixth month; the difference in the hypnosis group was not significant,…
    1 study · 30 participants
    GRADE not reported

Oral diclofenac sodium (NSAID) vs placebo

Daily pain (not improved) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral diclofenac sodium (NSAID) showed no clear difference in daily pain (not improved) compared with placebo; GRADE not reported.

1 finding from 1 review

Aesthetic (resin-veneered) crowns vs Conventional metal (stainless steel) crowns

Restoration failure · Children aged 12 years or younger with tooth decay involving at least one tooth in the primary dentition, symptomatic or symptom free

Aesthetic (resin-veneered) crowns showed no clear difference in restoration failure at 6 months compared with conventional metal (stainless steel) crowns; GRADE not reported.

1 finding from 1 review

Resorbable (bioresorbable) plates or screws for fixation vs Titanium plates or screws for fixation

Quality of life (validated questionnaire) · Adults over 18 years of age with fractures of the facial skeleton including the mandible, maxilla, zygoma (malar); studies on fractures of…

The review found no eligible studies for this question.

1 finding from 1 review
  • Resorbable versus titanium plates for facial fractures 2009 · Cochrane All outcomes
    Up to 3 years postoperatively
    Planned secondary outcome not assessed: none of the retrieved studies met the inclusion criteria, so no data were available for analysis. Verbatim (Effects of interventions): "Although 53 studies were retrieved in our…
    0 studies
    No studies found

Compomer (Dyract) vs Amalgam (Tytin)

Secondary caries · Children aged 12 years or younger with tooth decay involving at least one tooth in the primary dentition, symptomatic or symptom free

Compomer (Dyract) showed no clear difference in secondary caries at 24 months compared with amalgam (Tytin); GRADE not reported.

1 finding from 1 review