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Evidence found and GRADE certainty

4,411 questions · 5,986 findings · 226 reviews · Oral Health

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No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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Rubber/elastomeric cleaning stick plus toothbrushing vs Flossing plus toothbrushing

Side effects · Adults, 16 years and older (dentate)
1 finding from 1 review

Acupressure at P6 point with sea band vs sham

Adverse effects · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

The review found no eligible studies for this question.

1 finding from 1 review

Hyperbaric oxygen therapy (HBO) following extractions vs penicillin G

Incidence of ORN · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)

It is very uncertain whether hyperbaric oxygen therapy (HBO) following extractions changes incidence of ORN compared with perioperative antibiotic prophylaxis (penicillin G) following… (very low certainty).

1 finding from 1 review

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Major bleeding, requiring transfusion of packed red blood cells · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions
1 finding from 1 review

Thymosin alpha 1 (10-minute soak prior to replantation) vs Normal saline

Tooth survival · People with avulsed and replanted permanent (front) teeth

It is very uncertain whether thymosin alpha 1 (10-minute soak prior to replantation) changes tooth survival at 12 months compared with control (saline) (very low certainty).

2 findings from 1 review

Flossing plus toothbrushing vs Toothbrushing alone

Side effects · Adults, 16 years and older (dentate)
1 finding from 1 review

1000 mg champignon extract vs placebo

Adverse events · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

The review found no eligible studies for this question.

1 finding from 1 review
  • Interventions for managing halitosis 2019 · Cochrane All outcomes
    mean 2 weeks
    Adverse events: listed in the Summary of findings table but no data reported. No data were reported for adverse events.
    0 studies
    No studies found

Chlorine dioxide + zinc mouthwash vs Placebo mouthwash

Dentist-reported organoleptic test (OLT) score (scale 0 to 5) · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

It is very uncertain whether chlorine dioxide + zinc mouthwash changes dentist-reported organoleptic test (OLT) score (scale 0 to 5) compared with placebo mouthwash (very low certainty).

1 finding from 1 review

Acupressure at P6 point with device plus sedation vs Sham (dummy) acupressure with sedation

Reduction in gagging (patient-reported) · People (older than four years) classified as having gagging that interfered with dental treatment; included trials enrolled adults

It is very uncertain whether acupressure at P6 point with device plus sedation changes reduction in gagging (patient-reported) compared with sham (dummy) acupressure with sedation (very low certainty).

1 finding from 1 review

Slow-release fluoride device (fluoride glass beads) vs Fluoride mouthrinse

Number of participants with more severe DLs (severity of DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

The review found no eligible studies for this question.

1 finding from 1 review

Benzethonium chloride mouthwash vs Placebo mouthwash

VSC: methyl mercaptan · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Benzethonium chloride mouthwash showed no clear difference in VSC: methyl mercaptan compared with placebo mouthwash; GRADE not reported.

1 finding from 1 review

1055 to 1100 ppm F toothpaste vs 500 to 550 ppm F toothpaste

Caries increment, tooth index D(M)FT · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start)

1055 to 1100 ppm F toothpaste showed no clear difference in caries increment, tooth index d(m)ft compared with 500 to 550 ppm F toothpaste (low certainty).

1 finding from 1 review

Interdental brushing plus toothbrushing vs Flossing plus toothbrushing

Plaque · Adults, 16 years and older (dentate)

It is very uncertain whether interdental brushing plus toothbrushing changes plaque compared with flossing plus toothbrushing (very low certainty).

3 findings from 2 reviews · compare the 2 reviews

1400/250 ppm F (amine F/SnF2) toothpaste + mouthrinse, daily vs 1400/250 ppm F (NaF) toothpaste + mouthrinse, daily

Gingival bleeding (various bleeding indices) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

It is very uncertain whether 1400/250 ppm F (amine F/SnF2) toothpaste + mouthrinse, daily changes gingival bleeding index (mean change from baseline) compared with 1400/250 ppm F (NaF) toothpaste + mouthrinse, daily (very low certainty).

1 finding from 1 review

Rubber/elastomeric cleaning stick plus toothbrushing vs Interdental brushing plus toothbrushing

Gingivitis · Adults, 16 years and older (dentate)

It is very uncertain whether rubber/elastomeric cleaning stick plus toothbrushing changes gingivitis (proportion of bleeding sites) compared with interdental brushing plus toothbrushing (very low certainty).

2 findings from 1 review

0.05% chlorhexidine + 0.05% cetylpyridinium chloride + 0.14% zinc lactate mouthrinse vs Placebo mouthwash

Volatile sulphur compounds (VSC), halimeter · Adolescents and adults aged over 16 years with clinical or self-assessed halitosis of oral origin; excluding induced or physiological…

Halita mouthwash (chlorhexidine 0.05% + cetylpyridinium chloride… led to lower volatile sulphur compounds (VSC), halimeter compared with placebo mouthwash; GRADE not reported.

1 finding from 1 review