Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,756 questions · 13,493 findings · 1,305 reviews · Headline outcomes only

No studies found 2,594 · 19.2%GRADE not reported 728 · 5.4%Very low 2,868 · 21.3%Low 3,777 · 28%Moderate 2,620 · 19.4%High 906 · 6.7%

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Cannabis‐based medicines vs placebo medication

Daily breakthrough opioid dosage (mg morphine equivalent) · adults with cancer‐related pain

Cannabis‐based medicines showed no clear difference in daily breakthrough opioid dosage (mg morphine equivalent) compared with placebo medication (moderate certainty).

1 finding from 1 review

Remdesivir and standard care vs placebo or usual care

All‐cause mortality at up to day 281 · hospitalised individuals with COVID‐19 (moderate to severe disease)

Remdesivir and standard care showed no clear difference in all‐cause mortality at up to day 281 compared with standard care (plus/minus placebo) (moderate certainty).

1 finding from 1 review

Remdesivir and standard care vs placebo or usual care

Admission to hospital or death within 28 days · non‐hospitalised adults with mild COVID‐19

Remdesivir and standard care probably leads to lower clinical worsening: participants admitted to hospital or deceased at… compared with standard care (plus/minus placebo) (moderate certainty).

1 finding from 1 review

Remdesivir and standard care vs placebo or usual care

All‐cause mortality at up to day 60 · hospitalised individuals with COVID‐19 (moderate to severe disease)

Remdesivir and standard care showed no clear difference in all‐cause mortality at up to day 60 compared with standard care (plus/minus placebo) (moderate certainty).

1 finding from 1 review

Remdesivir and standard care vs placebo or usual care

In‐hospital mortality at up to day 150 · hospitalised individuals with COVID‐19 (moderate to severe disease)

Remdesivir and standard care showed no clear difference in in‐hospital mortality at up to day 150 compared with standard care (plus/minus placebo) (moderate certainty).

1 finding from 1 review

Remdesivir and standard care vs placebo or usual care

Clinical improvement: discharged alive ( · hospitalised individuals with COVID‐19 (moderate to severe disease)

Remdesivir and standard care probably leads to higher clinical improvement: participants alive and ready to be discharged… compared with standard care (plus/minus placebo) (moderate certainty).

1 finding from 1 review

Remdesivir and standard care vs placebo or usual care

Clinical worsening: new need for invasive mechanical ventilation or death · hospitalised individuals with COVID‐19 (moderate to severe disease)

Remdesivir and standard care probably leads to lower clinical worsening: time to new need for invasive mechanical… compared with standard care (plus/minus placebo) (moderate certainty).

1 finding from 1 review

Remdesivir and standard care vs placebo or usual care

Adverse events: all grades · hospitalised individuals with COVID‐19 (moderate to severe disease)

Remdesivir and standard care showed no clear difference in adverse events (any grade) at up to day 28 compared with standard care (plus/minus placebo) (low certainty).

1 finding from 1 review

Remdesivir and standard care vs placebo or usual care

Serious adverse events at up to day 28 · hospitalised individuals with COVID‐19 (moderate to severe disease)

Remdesivir and standard care showed no clear difference in serious adverse events at up to day 28 compared with standard care (plus/minus placebo) (low certainty).

1 finding from 1 review