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Evidence found and GRADE certainty

1,835 questions · 1,886 findings · 74 reviews · Skin

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No studies found 542 · 28.7%GRADE not reported 130 · 6.9%Very low 326 · 17.3%Low 434 · 23%Moderate 348 · 18.5%High 106 · 5.6%

Loratadine 10 mg vs mizolastine 10 mg

Proportion of participants with at least 50% improvement in QoL: intermediate‐term duration of intervention Symptom score reducing index (SSRI) · patients with chronic spontaneous urticaria

It is very uncertain whether loratadine 10 mg changes proportion of participants with at least 50% improvement in QoL:… compared with mizolastine 10 mg (very low certainty).

1 finding from 1 review

Loratadine 10 mg vs emedastine 2 mg

Complete cessation of urticaria: intermediate‐term duration of intervention Global assessment of symptom scores · patients with chronic spontaneous urticaria

Loratadine 10 mg showed no clear difference in complete cessation of urticaria: intermediate‐term duration of… compared with emedastine 2 mg (moderate certainty).

1 finding from 1 review

Loratadine 10 mg vs emedastine 2 mg

Good or excellent response: intermediate‐term duration of intervention Global assessment of symptom scores · patients with chronic spontaneous urticaria

Loratadine 10 mg showed no clear difference in good or excellent response: intermediate‐term duration of… compared with emedastine 2 mg (moderate certainty).

1 finding from 1 review

Loratadine 10 mg vs emedastine 2 mg

Withdrawals due to adverse events · patients with chronic spontaneous urticaria

Loratadine 10 mg showed no clear difference in adverse events leading to withdrawal: intermediate‐term duration of… compared with emedastine 2 mg (moderate certainty).

1 finding from 1 review

Loratadine 10 mg vs hydroxyzine 25 mg

Complete suppression of urticaria: short‐term duration of intervention Global assessment of symptom scores · patients with chronic spontaneous urticaria

Loratadine 10 mg showed no clear difference in complete suppression of urticaria: short‐term duration of… compared with hydroxyzine 25 mg (low certainty).

1 finding from 1 review

Hydroxyzine 25 mg vs placebo

Withdrawals due to adverse events · patients with chronic spontaneous urticaria

Hydroxyzine 25 mg showed no clear difference in adverse events leading to withdrawal: intermediate‐term duration of… compared with placebo (low certainty).

1 finding from 1 review

Desloratadine 5 to 20 mg vs placebo

Adverse effects requiring withdrawal/discontinuation of study medication · patients with chronic spontaneous urticaria

Desloratadine 5 to 20 mg showed no clear difference in adverse effects leading to withdrawal: intermediate‐term duration of… compared with placebo (low certainty).

1 finding from 1 review

Strong steroid (class III or IV) vs mild steroid (class I or II)

Total clearance (at 4 weeks or less) Investigator's assessment · patients with seborrhoeic dermatitis

Strong steroid (class III or IV) showed no clear difference in total clearance (at 4 weeks or less) Investigator's assessment compared with mild steroid (class I or II) (moderate certainty).

1 finding from 1 review

Strong steroid (class III or IV) vs mild steroid (class I or II)

Total clearance (more than 4 weeks) Investigator's assessment · patients with seborrhoeic dermatitis

Strong steroid (class III or IV) may leads to lower total clearance (more than 4 weeks) Investigator's assessment compared with mild steroid (class I or II) (low certainty).

1 finding from 1 review