Findings

What do systematic reviews say?

2,261 questions · 2,280 findings · 114 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 856 · 37.5%GRADE not reported 58 · 2.5%Very low 550 · 24.1%Low 502 · 22%Moderate 271 · 11.9%High 43 · 1.9%

Inhalation during vs after airway clearance techniques

Symptom scores · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Inhalation during vs after airway clearance techniques

Measures of sputum clearance · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Inhalation before vs during airway clearance techniques

FVC · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Inhalation during vs after airway clearance techniques

LCI · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Inhalation during vs after airway clearance techniques

Adverse events · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Inhalation before vs during airway clearance techniques

QoL · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Inhalation before vs during airway clearance techniques

Symptom scores · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 76 participants
Low

Inhalation before vs during airway clearance techniques

Expectorated secretions (sputum wet weight) · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 26 participants
Low

Inhalation before vs during airway clearance techniques

LCI · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 13 participants
Low

Inhalation before vs during airway clearance techniques

Adverse events · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Inhalation before vs after airway clearance techniques

FEV1 % predicted · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Inhalation before vs after airway clearance techniques

FVC · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Summary of findings: water‐soluble vitamin E vs control

Vitamin E total lipid ratio · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin E supplementation in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: fat‐soluble vitamin E vs control

Neuropathy due to vitamin E deficiency · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin E supplementation in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: fat‐soluble vitamin E vs control

Retinopathy due to vitamin E deficiency · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin E supplementation in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: fat‐soluble vitamin E vs control

Body‐mass index (BMI) · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin E supplementation in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: fat‐soluble vitamin E vs control

Height (cm) · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin E supplementation in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: fat‐soluble vitamin E vs control

FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin E supplementation in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: water‐soluble vitamin E vs control

Vitamin E levels in serum: umol/L · adults and children with cystic fibrosis

Summary of findings: water‐soluble vitamin E may leads to higher vitamin E levels in serum: umol/L compared with control (low certainty).

1 finding from 1 review

Vitamin E supplementation in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
MD 19.74 [13.48, 26]
1 study · 45 participants
Low

Summary of findings: water‐soluble vitamin E vs control

Neuropathy due to vitamin E deficiency · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Vitamin E supplementation in people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found