What do systematic reviews say?

Higher maternal circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower maternal circulating 25-hydroxyvitamin D (25(OH)D) concentration

Meta-analysis of observational studies (higher vs lower maternal 25(OH)D) for Birth weight: WMD 130.9 (95% CI 75.1 to 186.7), statistically significant. Umbrella review outcome-level evidence grade: Probable.

• Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational… 2014 All outcomes
  WMD 130.9 [75.1, 186.7]
  4 studies · 5541 participants
  GRADE not reported

Vitamin D vs placebo or control

Meta-analysis of randomised trials of vitamin D supplementation for Head circumference at birth: WMD 0.43 (95% CI 0.06 to 0.79), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.

• Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational… 2014 All outcomes
  WMD 0.43 [0.06, 0.79]
  2 studies
  GRADE not reported

Vitamin D vs placebo or control

Meta-analysis of randomised trials of vitamin D supplementation for Low birth weight: RR 0.4 (95% CI 0.23 to 0.71), statistically significant. Umbrella review outcome-level evidence grade: Probable.

• Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational… 2014 All outcomes
  RR 0.4 [0.23, 0.71]
  3 studies · 507 participants
  GRADE not reported

Higher maternal circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower maternal circulating 25-hydroxyvitamin D (25(OH)D) concentration

Meta-analysis of observational studies (higher vs lower maternal 25(OH)D) for Gestational diabetes: OR 0.67 (95% CI 0.53 to 0.85), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.

• Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational… 2014 All outcomes
  OR 0.67 [0.53, 0.85]
  10 studies · 4112 participants
  GRADE not reported

Vitamin D vs placebo or control

Meta-analysis of randomised trials of vitamin D supplementation for Birth length: WMD 0.97 (95% CI -0.41 to 2.34), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.

• Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational… 2014 All outcomes
  WMD 0.97 [-0.41, 2.34]
  2 studies
  GRADE not reported

Vitamin D vs placebo or control

Meta-analysis of randomised trials of vitamin D supplementation for Maternal vitamin D concentrations at term: WMD 47.08 (95% CI 23.76 to 70.39), statistically significant. Umbrella review outcome-level evidence grade: Probable.

• Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational… 2014 All outcomes
  WMD 47.08 [23.76, 70.39]
  4 studies
  GRADE not reported

Self etching primer (one-step etchant-and-primer technique) vs Conventional etchants (two-step etch and prime method using 37% phosphoric acid)

The review found no eligible studies for this question.

• Enamel etching for bonding fixed orthodontic braces 2013 · Cochrane All outcomes
  Cost of treatment: No studies assessed this outcome.
  Studies not reported
  No studies found

Self etching primer (one-step etchant-and-primer technique) vs Conventional etchants (two-step etch and prime method using 37% phosphoric acid)

The review found no eligible studies for this question.

• Enamel etching for bonding fixed orthodontic braces 2013 · Cochrane All outcomes
  Damage to the teeth: No studies assessed this outcome.
  Studies not reported
  No studies found

Any intervention to manage relapse: fixed options (labial braces, lingual braces, fixed lingual wire) or removable options (Hawley's retainer with spring elastomeric module, Bloore removable aligner, other Hawley's retainer modifications, Invisalign, Clearstep) vs no intervention or another intervention

The review found no eligible studies for this question.

• Interventions for managing relapse of the lower front teeth after orthodontic treatment 2013 · Cochrane All outcomes
  No RCTs met the inclusion criteria for this review. After deduplication, the electronic searching identified 527 publications; after reviewing the titles and abstracts, none focused on interventions to correct the…
  0 studies
  No studies found

Any intervention to manage relapse: fixed options (labial braces, lingual braces, fixed lingual wire) or removable options (Hawley's retainer with spring elastomeric module, Bloore removable aligner, other Hawley's retainer modifications, Invisalign, Clearstep) vs no intervention or another intervention

The review found no eligible studies for this question.

• Interventions for managing relapse of the lower front teeth after orthodontic treatment 2013 · Cochrane All outcomes
  No RCTs met the inclusion criteria for this review. After deduplication, the electronic searching identified 527 publications; after reviewing the titles and abstracts, none focused on interventions to correct the…
  0 studies
  No studies found

Any intervention to manage relapse: fixed options (labial braces, lingual braces, fixed lingual wire) or removable options (Hawley's retainer with spring elastomeric module, Bloore removable aligner, other Hawley's retainer modifications, Invisalign, Clearstep) vs no intervention or another intervention

The review found no eligible studies for this question.

• Interventions for managing relapse of the lower front teeth after orthodontic treatment 2013 · Cochrane All outcomes
  No RCTs met the inclusion criteria for this review. After deduplication, the electronic searching identified 527 publications; after reviewing the titles and abstracts, none focused on interventions to correct the…
  0 studies
  No studies found

Transbond Plus self etching primer (3M Unitek) vs Clearfil Protect Bond self etching primer (Kuraray Medical)

• Enamel etching for bonding fixed orthodontic braces 2013 · Cochrane All outcomes
  Self etching primers versus self etching primers: Two split-mouth studies compared two different SEPs (Noble 2006; Paschos 2009). The failure rates were reported at tooth level rather than at participant level. We…
  1 study
  GRADE not reported

Fee‐for‐service (FFS) vs no intervention or control intervention (control)

• The effect of different methods of remuneration on the behaviour of primary care dentists 2013 · Cochrane All outcomes

  18 months
  ICER 0.10
  1 study · 68 participants
  Very low

Any intervention to manage relapse: fixed options (labial braces, lingual braces, fixed lingual wire) or removable options (Hawley's retainer with spring elastomeric module, Bloore removable aligner, other Hawley's retainer modifications, Invisalign, Clearstep) vs no intervention or another intervention

The review found no eligible studies for this question.

• Interventions for managing relapse of the lower front teeth after orthodontic treatment 2013 · Cochrane All outcomes
  No RCTs met the inclusion criteria for this review. After deduplication, the electronic searching identified 527 publications; after reviewing the titles and abstracts, none focused on interventions to correct the…
  0 studies
  No studies found

PDHA program vs Baseline pre-intervention service-delivery scenario

The PDHA program was projected to increase clinic-based dental care utilization from 75% to 90%, without a GRADE rating.

• Reducing Alaska Native paediatric oral health disparities: a systematic review of oral health interventions and a case… 2013 All outcomes

  20 years · Alaska
  Percentage-point increase 15
  1 study
  GRADE not reported

Self etching primer (one-step etchant-and-primer technique) vs Conventional etchants (two-step etch and prime method using 37% phosphoric acid)

Self etching primers (one-step etchant and primer system) showed no clear difference in bond failure rate compared with conventional etchants (two-step etch and prime method using 37%… (low certainty).

• Enamel etching for bonding fixed orthodontic braces 2013 · Cochrane All outcomes

  5 to 37 months
  RR 1.14 [0.75, 1.73]
  5 studies · 221 participants
  Low

Fee‐for‐service (FFS) vs no intervention or control intervention (control)

It is very uncertain whether fee-for-service remuneration changes measures of clinical activity: mean percentage of 12- to… compared with no specific intervention (control) (very low certainty).

• The effect of different methods of remuneration on the behaviour of primary care dentists 2013 · Cochrane All outcomes

  18 months
  RD 7.1 [-1.9, 16.1]
  1 study · 133 participants
  Very low

Transbond Plus self etching primer (3M Unitek) vs Clearfil Protect Bond self etching primer (Kuraray Medical)

• Enamel etching for bonding fixed orthodontic braces 2013 · Cochrane All outcomes
  Decalcification outcomes in Paschos 2009 were reported at tooth level rather than at participant level; the evidence was insufficient to conclude whether or not there is a difference in decalcification between the…
  1 study
  GRADE not reported

Any intervention to manage relapse: fixed options (labial braces, lingual braces, fixed lingual wire) or removable options (Hawley's retainer with spring elastomeric module, Bloore removable aligner, other Hawley's retainer modifications, Invisalign, Clearstep) vs no intervention or another intervention

The review found no eligible studies for this question.

• Interventions for managing relapse of the lower front teeth after orthodontic treatment 2013 · Cochrane All outcomes
  No RCTs met the inclusion criteria for this review. After deduplication, the electronic searching identified 527 publications; after reviewing the titles and abstracts, none focused on interventions to correct the…
  0 studies
  No studies found

Any intervention to manage relapse: fixed options (labial braces, lingual braces, fixed lingual wire) or removable options (Hawley's retainer with spring elastomeric module, Bloore removable aligner, other Hawley's retainer modifications, Invisalign, Clearstep) vs no intervention or another intervention

The review found no eligible studies for this question.

• Interventions for managing relapse of the lower front teeth after orthodontic treatment 2013 · Cochrane All outcomes
  No RCTs met the inclusion criteria for this review. After deduplication, the electronic searching identified 527 publications; after reviewing the titles and abstracts, none focused on interventions to correct the…
  0 studies
  No studies found