Findings

What do systematic reviews say?

2,261 questions · 2,280 findings · 114 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 856 · 37.5%GRADE not reported 58 · 2.5%Very low 550 · 24.1%Low 502 · 22%Moderate 271 · 11.9%High 43 · 1.9%

Summary of findings ‐ Inhaled mannitol plus dornase alfa vs dornase alfa

FEV1 % predicted · children and young adults with CF

The review found no eligible studies for this question.

1 finding from 1 review

Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Inhaled mannitol plus dornase alfa vs dornase alfa

FVC · children and young adults with CF

It is very uncertain whether summary of findings ‐ Inhaled mannitol plus dornase alfa changes lung function: FVC mL (percentage change from baseline) compared with dornase alfa (very low certainty).

1 finding from 1 review

Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
231 participants
Very low

Summary of findings ‐ Inhaled mannitol plus dornase alfa vs dornase alfa

Lung function: FEF25‐75 mL/s (percentage change from baseline) · children and young adults with CF

It is very uncertain whether summary of findings ‐ Inhaled mannitol plus dornase alfa changes lung function: FEF25-75 mL/s (percentage change from baseline) compared with dornase alfa (very low certainty).

1 finding from 1 review

Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
231 participants
Very low

Summary of findings ‐ 400 mg inhaled mannitol vs 50 mg inhaled mannitol

FEV1 % predicted: absolute change from baseline · adults, children and young people with CF

1 finding from 1 review

Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 600 participants
Moderate

Summary of findings ‐ Inhaled mannitol plus dornase alfa vs dornase alfa

Adverse events relating to treatment Scale: mild, moderate, severe and total · children and young adults with CF

1 finding from 1 review

Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
231 participants
Very low

Summary of findings ‐ 400 mg inhaled mannitol vs 50 mg inhaled mannitol

FVC · adults, children and young people with CF

1 finding from 1 review

Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 600 participants
Moderate

Summary of findings ‐ 400 mg inhaled mannitol vs 50 mg inhaled mannitol

Lung function: FEF25‐75 mL/s (change from baseline) · adults, children and young people with CF

1 finding from 1 review

Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 600 participants
Moderate

Summary of findings ‐ 400 mg inhaled mannitol vs 50 mg inhaled mannitol

Adverse events relating to treatment Scale: mild, moderate, severe and total · adults, children and young people with CF

1 finding from 1 review

Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 600 participants
Moderate

Summary of findings ‐ Inhaled mannitol vs control (non‐respirable mannitol)

HRQoL ‐ all domains (change from baseline) Scale: age‐appropriate versions of the CFQ‐R questionnaire · adults, children and young people with CF

1 finding from 1 review

Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
391 participants
Very low

Summary of findings ‐ Inhaled mannitol vs control (non‐respirable mannitol)

Lung function: FEV1 mL (change from baseline) · adults, children and young people with CF

1 finding from 1 review

Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 391 participants
Low

Summary of findings ‐ Inhaled mannitol vs control (non‐respirable mannitol)

FEV1 % predicted: absolute change from baseline · adults, children and young people with CF

1 finding from 1 review

Inhaled mannitol for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1261 participants
Low

Inhalation before vs during airway clearance techniques

FEV1 % predicted · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 63 participants
Low

Inhalation before vs after airway clearance techniques

QoL · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Inhalation before vs after airway clearance techniques

Symptom scores · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Inhalation before vs after airway clearance techniques

Measures of sputum clearance · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Inhalation before vs after airway clearance techniques

LCI · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Inhalation before vs after airway clearance techniques

Adverse events · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Inhalation during vs after airway clearance techniques

FEV1 % predicted · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Inhalation during vs after airway clearance techniques

FVC · adults and children with cystic fibrosis

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Inhalation during vs after airway clearance techniques

QoL · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Timing of hypertonic saline inhalation for cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found