Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,922 questions · 3,118 findings · 513 reviews

No studies found 574 · 18.4%GRADE not reported 372 · 11.9%Very low 723 · 23.2%Low 854 · 27.4%Moderate 489 · 15.7%High 106 · 3.4%

Prostacyclin vs control

Improvement in WHO functional class · pulmonary arterial hypertension

Prostacyclin probably leads to higher improvement in WHO functional class compared with control (moderate certainty).

1 finding from 1 review

Selexipag vs placebo

Improvement in WHO functional class · pulmonary arterial hypertension

Selexipag showed no clear difference in improvement in WHO functional class compared with placebo (moderate certainty).

1 finding from 1 review

Glutaraldehyde + zinc oxide and eugenol (ZOE) vs Full strength formocresol (FC)

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Glutaraldehyde + zinc oxide and eugenol (ZOE) showed no clear difference in clinical failure compared with full strength formocresol (FC); GRADE not reported.

1 finding from 1 review

Metapex (calcium hydroxide/iodoform) vs Endoflas chlorophenol free (Endoflas-CF)

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Metapex (calcium hydroxide/iodoform) showed no clear difference in radiological failure compared with endoflas chlorophenol free (Endoflas-CF); GRADE not reported.

1 finding from 1 review