Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,297 questions · 3,638 findings · 215 reviews · All outcomes

No studies found 98 · 2.7%GRADE not reported 2,946 · 81%Very low 263 · 7.2%Low 158 · 4.3%Moderate 137 · 3.8%High 36 · 1%

CT + TT genotype (T-allele carriers) of AMELX rs946252 vs CC genotype of AMELX rs946252

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between CT + TT genotype (T-allele carriers) vs CC genotype of AMELX rs946252 and dental caries susceptibility (CT + TT vs CC model: OR 1.63, 95% CI 0.67-4.01) in the Ethnicity: Caucasian subgroup; certainty not graded.

6 findings from 1 review
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T allele of AMELX rs946252 vs C allele of AMELX rs946252

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between T allele vs C allele of AMELX rs946252 and dental caries susceptibility (T vs C model: OR 0.99, 95% CI 0.53-1.86) in the Ethnicity: Mixed subgroup; certainty not graded.

6 findings from 1 review
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G allele of ENAM rs3796704 vs A allele of ENAM rs3796704

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between G allele vs A allele of ENAM rs3796704 and dental caries susceptibility (G vs A model: OR 1.11, 95% CI 0.57-2.15) in the Ethnicity: Mixed subgroup; certainty not graded.

6 findings from 1 review
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G allele of ENAM rs1264848 vs A allele of ENAM rs1264848

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between G allele vs A allele of ENAM rs1264848 and dental caries susceptibility (G vs A model: OR 0.93, 95% CI 0.65-1.32); certainty not graded.

6 findings from 1 review
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AG genotype of ENAM rs3796704 vs AA genotype of ENAM rs3796704

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between AG genotype vs AA genotype of ENAM rs3796704 and dental caries susceptibility (AG vs AA model: OR 0.35, 95% CI 0.07-1.74) in the Age group: Children subgroup; certainty not graded.

6 findings from 1 review
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CT + TT genotype (T-allele carriers) of AMELX rs17878486 vs CC genotype of AMELX rs17878486

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

The CT + TT genotype (T-allele carriers) of AMELX rs17878486 was associated with increased dental caries risk (CT + TT vs CC model: OR 5.72, 95% CI 2.83-11.59) after excluding the outlier study (Ergoz 2014); certainty not graded.

9 findings from 1 review
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AG genotype of LTF rs1126478 vs AA genotype of LTF rs1126478

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between AG genotype vs AA genotype of LTF rs1126478 and dental caries susceptibility (AG vs AA model: OR 1.07, 95% CI 0.80-1.43) in the Ethnicity: Asian subgroup; certainty not graded.

5 findings from 1 review
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CT + TT genotype (T-allele carriers) of AMELX rs6639060 vs CC genotype of AMELX rs6639060

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between CT + TT genotype (T-allele carriers) vs CC genotype of AMELX rs6639060 and dental caries susceptibility (CT + TT vs CC model: OR 1.14, 95% CI 0.56-2.29) in the Ethnicity: Caucasian subgroup; certainty not graded.

3 findings from 1 review

TT genotype of AMELX rs946252 vs CC genotype of AMELX rs946252

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between TT genotype vs CC genotype of AMELX rs946252 and dental caries susceptibility (TT vs CC model: OR 1.54, 95% CI 0.61-3.92) in the Age group: Children subgroup; certainty not graded.

6 findings from 1 review
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Tooth-coloured direct restorative materials (composite, compomer, giomer, RMGIC, HVGIC, open-sandwich) vs No comparator

Marginal integrity success rate · Children with primary molars requiring proximal (Class II) restorations

After trim-and-fill adjustment the marginal integrity success rate was 0.881 (95% CI 0.832-0.916; ungraded), a negligible change.

2 findings from 1 review

GG genotype of ENAM rs3796704 vs AA genotype of ENAM rs3796704

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between GG genotype vs AA genotype of ENAM rs3796704 and dental caries susceptibility (GG vs AA model: OR 1.86, 95% CI 0.96-3.62); certainty not graded.

6 findings from 1 review
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No additional acid etching (self-etch adhesive alone) after Er,Cr:YSGG preparation vs Prior acid etching before self-etch adhesive after Er,Cr:YSGG preparation

Incidence of microleakage · Er,Cr:YSGG laser-prepared cavities restored with self-etch adhesive systems (in vitro)

At the dentin margin, prior acid etching with self-etch adhesives significantly reduced microleakage (RR 2.44, 95% CI 1.38-4.34; ungraded).

3 findings from 1 review

AG + GG genotype (G-allele carriers) of LTF rs1126478 vs AA genotype of LTF rs1126478

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between AG + GG genotype (G-allele carriers) vs AA genotype of LTF rs1126478 and dental caries susceptibility (AG + GG vs AA model: OR 0.99, 95% CI 0.81-1.23) in the Age group: Children subgroup; certainty not graded.

5 findings from 1 review
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