Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,721 questions · 19,640 findings · 2,039 reviews · Headline outcomes only

No studies found 3,754 · 19.1%GRADE not reported 1,273 · 6.5%Very low 4,859 · 24.7%Low 5,568 · 28.4%Moderate 3,240 · 16.5%High 946 · 4.8%

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Primary health professional‐led psychological interventions vs usual care or no treatment

Anxiety and depression · adults with post‐traumatic stress or common mental disorders

Primary health professional‐led psychological interventions may leads to higher prevalence of adults with probable depression or anxiety (1 to 6… compared with usual or no care (low certainty).

1 finding from 1 review

Primary health professional‐led psychological interventions vs usual care or no treatment

Depression symptoms (1 to 6 months post intervention) Hopkins Symptom Checklist ‐ depression (higher score = higher severity) · adults with post‐traumatic stress or common mental disorders

It is very uncertain whether primary health professional‐led psychological interventions changes depression symptoms (1 to 6 months post intervention) Hopkins… compared with usual or no care (very low certainty).

1 finding from 1 review

Lay health worker‐led interventions for adult patients with harmful or hazardous alcohol or substance use vs enhanced usual care

Prevalence of methamphetamine use (1 to 6 months post intervention) (RR < 1 denotes lower prevalence compared to control) · adult patients with harmful or hazardous alcohol or substance use

Lay health worker‐led interventions for adult patients with harmful… showed no clear difference in prevalence of methamphetamine use (1 to 6 months post intervention)… compared with enhanced usual care (low certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Cannabis use · adult patients with harmful or hazardous alcohol or substance use

It is very uncertain whether primary health professional‐ and community professional‐led… changes prevalence of cannabis use (1 to 6 months post intervention) (RR < 1… compared with enhanced usual care (very low certainty).

1 finding from 1 review

Lay health worker‐ vs enhanced usual care

Clinical symptoms ‐ depression (1 to 6 months post intervention) · adult patients with alcohol dependence

It is very uncertain whether lay health worker‐led interventions changes clinical symptoms ‐ depression (1 to 6 months post intervention) compared with enhanced usual care (very low certainty).

1 finding from 1 review

Primary health professional‐ and community professional‐led interventions vs enhanced usual care

Prevalence of morphine use · adult patients with substance dependence

It is very uncertain whether primary health professional‐ and community professional‐led… changes prevalence of morphine use compared with enhanced usual care (very low certainty).

1 finding from 1 review

Primary‐level worker‐led collaborative care vs usual care

Prevalence of CMD ‐ intermediate term (1 to 6 months post intervention) Diagnosis defined by presence of ICD‐10 diagnosis on CIS‐Rg; prevalence defined by [Total number ‐ number recovered (recovery defined by HDRS < 8)]c (RR < 1 denotes lower prev... · adults with common mental disorders

Primary‐level worker‐led collaborative care showed no clear difference in prevalence of CMD ‐ intermediate term (1 to 6 months post… compared with usual care (low certainty).

1 finding from 1 review

Fornix vs limbal‐based conjunctival trabeculectomy flaps

Mean intraocular pressure · People with glaucoma

Fornix showed no clear difference in mean intraocular pressure compared with limbal‐based conjunctival trabeculectomy flaps (moderate certainty).

2 findings from 1 review

Endometrial injury vs control

Clinical pregnancy · women undergoing assisted reproduction

Endometrial injury showed no clear difference in clinical pregnancy per woman randomised (studies at low risk of… compared with control (moderate certainty).

2 findings from 1 review

Endometrial injury vs control

Clinical pregnancy per woman randomised: sensitivity analysis (no high‐risk) · women undergoing assisted reproduction

Endometrial injury showed no clear difference in clinical pregnancy per woman randomised: sensitivity analysis (no… compared with control (low certainty).

1 finding from 1 review