Deep vein thrombosis · people undergoing definitive fixation of hip, pelvic and long bone fractures
It is very uncertain whether intravenous tranexamic acid changes risk of deep vein thrombosis (30 days post‐surgery) compared with placebo (very low certainty).
1 finding from 1 review
Risk of suspected serious drug reactions (30 days post‐surgery) · people undergoing definitive fixation of hip, pelvic and long bone fractures
It is very uncertain whether intravenous tranexamic acid changes risk of suspected serious drug reactions (30 days post‐surgery) compared with placebo (very low certainty).
1 finding from 1 review
Risk of requiring allogeneic blood transfusion (30 days post‐surgery) · people undergoing definitive fixation of hip, pelvic and long bone fractures
It is very uncertain whether topical tranexamic acid changes risk of requiring allogeneic blood transfusion (30 days post‐surgery) compared with placebo (very low certainty).
1 finding from 1 review
All‐cause mortality (30 days post‐surgery) · people undergoing definitive fixation of hip, pelvic and long bone fractures
It is very uncertain whether topical tranexamic acid changes all‐cause mortality (30 days post‐surgery) compared with placebo (very low certainty).
1 finding from 1 review
Adverse effects · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)
1 finding from 1 review
Adverse effects were an outcome of interest in the study conducting this comparison, however no mention was made of the presence or absence of any adverse events
1 study · 220 participants
Very low
Incidence of ORN · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)
It is very uncertain whether hyperbaric oxygen therapy (HBO) following extractions changes incidence of ORN compared with perioperative antibiotic prophylaxis (penicillin G) following… (very low certainty).
1 finding from 1 review
Adverse effects · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)
1 finding from 1 review
Adverse effects were an outcome of interest in the study conducting this comparison, however no mention was made of the presence or absence of any adverse events
1 study · 74 participants
Very low
Fracture · preventing bone disease in kidney transplant recipients
Bisphosphonate showed no clear difference in fracture compared with placebo or no treatment (low certainty).
1 finding from 1 review
Death (all causes) · preventing bone disease in kidney transplant recipients
It is very uncertain whether vitamin D changes death (all causes) compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Cardiovascular mortality · preventing bone disease in kidney transplant recipients
It is very uncertain whether vitamin D changes cardiovascular death compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Graft loss · preventing bone disease in kidney transplant recipients
It is very uncertain whether vitamin D changes graft loss compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Acute rejection · preventing bone disease in kidney transplant recipients
Bisphosphonate may leads to lower acute graft rejection compared with placebo or no treatment (low certainty).
1 finding from 1 review
Death (all causes) · preventing bone disease in kidney transplant recipients
It is very uncertain whether bisphosphonate changes death (all causes) compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Cardiovascular mortality · preventing bone disease in kidney transplant recipients
It is very uncertain whether bisphosphonate changes cardiovascular death compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Spinal deformity · preventing bone disease in kidney transplant recipients
It is very uncertain whether bisphosphonate changes spinal deformity compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Hypocalcaemia · preventing bone disease in kidney transplant recipients
It is very uncertain whether bisphosphonate changes hypocalcaemia compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Fracture · preventing bone disease in kidney transplant recipients
It is very uncertain whether vitamin D changes fracture compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Acute rejection · preventing bone disease in kidney transplant recipients
It is very uncertain whether vitamin D changes acute graft rejection compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Incidence of ORN · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)
It is very uncertain whether PRP (platelet-rich plasma) in cellulose foam placed in extraction… changes incidence of ORN compared with no treatment/placebo (cellulose foam only) placed in extraction socket (very low certainty).
1 finding from 1 review
Incidence of ORN · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)
1 finding from 1 review
This comparison was only made in 1 study, which showed no difference between the 2 interventions: no patients in either group developed ORN (12- to 36-month follow-up) (0/99 in the fluoride gel group and 0/91 in the…
1 study · 220 participants
Very low