Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,935 questions · 1,986 findings · 260 reviews · Headline outcomes only

No studies found 503 · 25.3%GRADE not reported 76 · 3.8%Very low 593 · 29.9%Low 509 · 25.6%Moderate 241 · 12.1%High 64 · 3.2%

IFN‐α + PUVA vs PUVA

Improvement of quality of life · people with mycosis fungoides

The review found no eligible studies for this question.

1 finding from 1 review

Bexarotene + PUVA vs PUVA

Common adverse effects ‐ Photosensitivity (Time point of measurement: up to 16 weeks) · people with mycosis fungoides

Bexarotene + PUVA showed no clear difference in common adverse effects ‐ Photosensitivity (Time point of… compared with PUVA alone (low certainty).

1 finding from 1 review

Bexarotene + PUVA vs PUVA

Complete response · people with mycosis fungoides

Bexarotene + PUVA showed no clear difference in complete response (Time point of measurement: up to 16 weeks) compared with PUVA alone (low certainty).

1 finding from 1 review

Bexarotene + PUVA vs PUVA

Objective response rate · people with mycosis fungoides

Bexarotene + PUVA showed no clear difference in objective response rate (Time point of measurement: up to 16 weeks) compared with PUVA alone (low certainty).

1 finding from 1 review

IFN‐α + PUVA vs PUVA

Complete response · people with mycosis fungoides

IFN‐α + PUVA showed no clear difference in complete response (CR) compared with PUVA alone (low certainty).

1 finding from 1 review

Laxative plus bulking agent vs laxative alone

Adverse effects on women: faecal incontinence during first 10 postpartum days · postpartum women who underwent surgical repair of third degree perineal tears

It is very uncertain whether laxative plus bulking agent changes adverse effects on women: faecal incontinence during first 10… compared with laxative alone (very low certainty).

1 finding from 1 review