Aggressive prostate cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Aggressive prostate cancer: OR 0.98 (95% CI 0.84 to 1.15), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.
1 finding from 1 review
Cardiovascular mortality · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Cardiovascular disease mortality: RR 0.55 (95% CI 0.36 to 0.85), statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Birth length · pregnant women and their infants..
Meta-analysis of observational studies (higher vs lower maternal 25(OH)D) for Birth length: WMD 0.19 (95% CI -0.26 to 0.65), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.
1 finding from 1 review
Colorectal cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 1,25(OH)2D) for Colorectal cancer: OR 1.01 (95% CI 0.59 to 1.73), not statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
OR 1.01 [0.59, 1.73]
4 studies
GRADE not reported
Cardiovascular disease (prevalent) · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Cardiovascular disease (prevalent): OR 0.67 (95% CI 0.55 to 0.82), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Failure to correct the anterior open bite (open bite not closed) · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
Frankel's function regulator-4 (FR-4) with lip-seal training led to lower failure to correct the anterior open bite (open bite not closed) compared with no treatment; GRADE not reported.
1 finding from 1 review
Signs and symptoms of atypical swallowing and speech production disturbances · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
The review found no eligible studies for this question.
1 finding from 1 review
Tuberculosis · Participants in observational studies
The meta-analysis of observational studies reported a SMD (to OR) of 0.29 (95% CI 0.19 to 0.46) for higher versus lower circulating vitamin D concentration.
1 finding from 1 review
Birthweight (g) · pregnant women and their infants..
Meta-analysis of observational studies (higher vs lower maternal 25(OH)D) for Birth weight: WMD 130.9 (95% CI 75.1 to 186.7), statistically significant. Umbrella review outcome-level evidence grade: Probable.
1 finding from 1 review
Ovarian cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Ovarian cancer: OR 0.83 (95% CI 0.63 to 1.09), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Stroke · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Stroke: RR 0.61 (95% CI 0.50 to 0.75), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Signs and symptoms of respiratory disease · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
The review found no eligible studies for this question.
1 finding from 1 review
Breast cancer · Participants in observational studies
The meta-analysis of observational studies reported a OR of 0.99 (95% CI 0.68 to 1.47) for higher versus lower circulating vitamin D concentration.
1 finding from 1 review
Colon cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Colon cancer: OR 0.78 (95% CI 0.56 to 1.07), not statistically significant. Umbrella review outcome-level evidence grade: No conclusion.
1 finding from 1 review
Side effects / adverse effects (unilateral crossbite; transverse problems) · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review
Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomesAbout 4 months (treatment interrupted early)
"After 4 months the open bite was observed to close in the magnet group, but in four out of these ten patients, transverse problems were observed (unilateral crossbite) which led to the interruption of the treatment…
1 study · 10 participants
GRADE not reported
Position of the incisors (upper incisor inclination) · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review
The angulation of the upper incisors with the palatal plane (1/ANSPNS) decreased on average 0.3 (SD 4.6) degrees in the control group, whereas in the treated group the mean retrusion was 4 (SD 4.6) degrees, P < 0.01.…
1 study
GRADE not reported
Colorectal cancer · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Colorectal cancer: RR 0.70 (95% CI 0.58 to 0.84), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Alteration of hyperdivergent growth pattern · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
1 finding from 1 review
CVD · Adults (general population)
Meta-analysis of observational studies (higher vs lower 25(OH)D) for Cardiovascular disease: RR 0.66 (95% CI 0.57 to 0.77), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.
1 finding from 1 review
Economic evaluation (costs) · Children and adolescents (over 80% aged 16 years or younger at treatment start) with anterior open bite (lack of vertical overlap or…
The review found no eligible studies for this question.
1 finding from 1 review