Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,016 questions · 2,067 findings · 222 reviews · Headline outcomes only

No studies found 471 · 22.8%GRADE not reported 108 · 5.2%Very low 570 · 27.6%Low 458 · 22.2%Moderate 363 · 17.6%High 97 · 4.7%

Anaerobic coverage only vs gram‐positive, gram‐negative, and anaerobic coverage

Intra‐abdominal infection · people undergoing laparotomy for penetrating abdominal trauma

It is very uncertain whether anaerobic coverage only changes intra‐abdominal infection compared with gram‐positive, gram‐negative, and anaerobic coverage (very low certainty).

1 finding from 1 review

Azithromycin vs doxycycline

Microbiological failure Men · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

Azithromycin probably leads to higher microbiological failure Men compared with doxycycline (moderate certainty).

1 finding from 1 review

Doxycycline vs quinolones

Microbiological failure Men and women Doxycycline 100 mg twice a day for 7 days vs ofloxacin 300 mg once a day for 7 days · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…
1 finding from 1 review

Doxycycline vs quinolones

Adverse events (Analysis 1.7) Participant's report · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

It is very uncertain whether doxycycline changes adverse events Men and women Assessed by participants' self‐report compared with quinolones (very low certainty).

1 finding from 1 review

Doxycycline vs quinolones

Clinical failure Men Doxycycline 100 mg twice a day for 7 days vs ofloxacin 400 mg once a day for 7 days · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

It is very uncertain whether doxycycline changes clinical failure Men Doxycycline 100 mg twice a day for 7 days vs… compared with quinolones (very low certainty).

1 finding from 1 review

Doxycycline vs quinolones

Clinical failure Women Doxycycline 100 mg twice a day for 7 days vs ofloxacin 400 mg once a day for 7 days. · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

It is very uncertain whether doxycycline changes clinical failure Women Doxycycline 100 mg twice a day for 7 days vs… compared with quinolones (very low certainty).

1 finding from 1 review

Azithromycin vs doxycycline

Microbiological failure Women · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

It is very uncertain whether azithromycin changes microbiological failure Women compared with doxycycline (very low certainty).

1 finding from 1 review

Azithromycin vs doxycycline

Adverse events Men · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

Azithromycin showed no clear difference in adverse events Men compared with doxycycline (low certainty).

1 finding from 1 review

Azithromycin vs doxycycline

Adverse events Men and women · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

Azithromycin probably leads to lower adverse events Men and women compared with doxycycline (moderate certainty).

1 finding from 1 review

Azithromycin vs doxycycline

Clinical failure Men · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

Azithromycin showed no clear difference in clinical failure Men compared with doxycycline (low certainty).

1 finding from 1 review

Doxycycline vs quinolones

Microbiological failure Men · men and non‐pregnant women with symptomatic (uterine cervicitis and urethritis), or asymptomatic genital CT infection, diagnosed by cell…

It is very uncertain whether doxycycline changes microbiological failure Men Doxycycline 100 mg twice a day for 7… compared with quinolones (very low certainty).

1 finding from 1 review