What do systematic reviews say?

CBT vs waiting list control

It is very uncertain whether CBT changes depression scales (BDI‐II, HAM‐D and HADS); higher score means more… compared with wait‐list control (very low certainty).

• Non‐pharmacological interventions for depression in adults and children with traumatic brain injury 2015 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 146 participants
  Very low

CBT vs supportive psychotherapy

It is very uncertain whether CBT changes beck Depression Inventory (BDI); higher score means more depressed compared with supportive Psychotherapy (very low certainty).

• Non‐pharmacological interventions for depression in adults and children with traumatic brain injury 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 48 participants
  Very low

Repetitive transcranial magnetic stimulation (rTMS) vs rTMS plus Tricyclic Anti‐depressant

It is very uncertain whether repetitive transcranial magnetic stimulation (rTMS) changes hamilton Rating Scale for Depression (HAM‐D); higher score means… compared with rTMS plus Tricyclic Anti‐depressant (very low certainty).

• Non‐pharmacological interventions for depression in adults and children with traumatic brain injury 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 63 participants
  Very low

Supervised exercised vs exercise

Supervised exercised showed no clear difference in beck Depression Inventory (BDI); higher score means more depression compared with exercise (low certainty).

• Non‐pharmacological interventions for depression in adults and children with traumatic brain injury 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 77 participants
  Low

Intervention not reported

• Pharmacological interventions for unilateral spatial neglect after stroke 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  Very low

Intervention not reported

• Pharmacological interventions for unilateral spatial neglect after stroke 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  Very low

Intervention not reported

• Pharmacological interventions for unilateral spatial neglect after stroke 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  Very low

Intervention not reported

• Pharmacological interventions for unilateral spatial neglect after stroke 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  Very low

Intervention not reported

• Pharmacological interventions for unilateral spatial neglect after stroke 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  Very low

Intervention not reported

• Pharmacological interventions for unilateral spatial neglect after stroke 2015 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 20 participants
  Very low

Intervention not reported

The review found no eligible studies for this question.

• Pharmacological interventions for unilateral spatial neglect after stroke 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Pharmacological interventions for unilateral spatial neglect after stroke 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Pharmacological interventions for unilateral spatial neglect after stroke 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Donepezil vs placebo

• Pharmacological interventions for cognitive decline in people with Down syndrome 2015 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 165 participants
  Low

Memantine vs placebo

The review found no eligible studies for this question.

• Pharmacological interventions for cognitive decline in people with Down syndrome 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Memantine vs placebo

The review found no eligible studies for this question.

• Pharmacological interventions for cognitive decline in people with Down syndrome 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Memantine vs placebo

The review found no eligible studies for this question.

• Pharmacological interventions for cognitive decline in people with Down syndrome 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Donepezil vs placebo

• Pharmacological interventions for cognitive decline in people with Down syndrome 2015 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 157 participants
  Low

Donepezil vs placebo

Comparison 1: donepezil may leads to lower adverse events compared with placebo (low certainty).

• Pharmacological interventions for cognitive decline in people with Down syndrome 2015 · Cochrane Headline outcomes only
  OR 0.32 [0.16, 0.62]
  4 studies · 192 participants
  Low

Donepezil vs placebo

The review found no eligible studies for this question.

• Pharmacological interventions for cognitive decline in people with Down syndrome 2015 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found