Findings

What do systematic reviews say?

1,741 questions · 1,821 findings · 207 reviews

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No studies found 297 · 16.3%GRADE not reported 191 · 10.5%Very low 333 · 18.3%Low 466 · 25.6%Moderate 414 · 22.7%High 120 · 6.6%

Oxcarbazepine vs phenytoin

Time to treatment failure (any reason related to treatment) Subgroup: generalised onset seizures Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine showed no clear difference in time to treatment failure (any reason related to treatment)… compared with phenytoin (primary outcomes) (moderate certainty).

1 finding from 1 review

Oxcarbazepine versus phenytoin monotherapy for epilepsy: an individual participant data review 2018 · Cochrane Headline outcomes only
HR 1.03 [0.51, 2.08]
2 studies · 143 participants
Moderate

Oxcarbazepine vs phenytoin

Time to treatment failure due to adverse events All participants Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine leads to lower time to treatment failure due to adverse events All participants… compared with phenytoin (primary outcomes) (high certainty).

1 finding from 1 review

Oxcarbazepine versus phenytoin monotherapy for epilepsy: an individual participant data review 2018 · Cochrane Headline outcomes only
HR 0.22 [0.1, 0.51]
2 studies · 480 participants
High

Oxcarbazepine vs phenytoin

Time to treatment failure due to lack of efficacy All participants Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine showed no clear difference in time to treatment failure due to lack of efficacy All participants… compared with phenytoin (primary outcomes) (moderate certainty).

1 finding from 1 review

Oxcarbazepine versus phenytoin monotherapy for epilepsy: an individual participant data review 2018 · Cochrane Headline outcomes only
HR 1.17 [0.31, 4.35]
2 studies · 480 participants
Moderate

Oxcarbazepine vs phenytoin

Time to first seizure (post‐randomisation) All participants Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine showed no clear difference in time to first seizure (post‐randomisation) All participants Range of compared with phenytoin (secondary outcomes) (moderate certainty).

1 finding from 1 review

Oxcarbazepine versus phenytoin monotherapy for epilepsy: an individual participant data review 2018 · Cochrane Headline outcomes only
HR 0.97 [0.75, 1.26]
2 studies · 468 participants
Moderate

Oxcarbazepine vs phenytoin

Time to first seizure (post‐randomisation) Subgroup: focal onset seizures Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine showed no clear difference in time to first seizure (post‐randomisation) Subgroup: focal onset… compared with phenytoin (secondary outcomes) (moderate certainty).

1 finding from 1 review

Oxcarbazepine versus phenytoin monotherapy for epilepsy: an individual participant data review 2018 · Cochrane Headline outcomes only
HR 0.92 [0.68, 1.25]
2 studies · 326 participants
Moderate

Oxcarbazepine vs phenytoin

Time to first seizure (post‐randomisation) Subgroup: generalised onset seizures Range of · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine showed no clear difference in time to first seizure (post‐randomisation) Subgroup: generalised… compared with phenytoin (secondary outcomes) (low certainty).

1 finding from 1 review

Oxcarbazepine versus phenytoin monotherapy for epilepsy: an individual participant data review 2018 · Cochrane Headline outcomes only
HR 1.11 [0.66, 1.86]
2 studies · 142 participants
Low

Oxcarbazepine vs phenytoin

Remission · people with newly diagnosed epilepsy

Summary of findings: oxcarbazepine showed no clear difference in time to achieve 12‐month remission (seizure‐free period) All… compared with phenytoin (secondary outcomes) (moderate certainty).

1 finding from 1 review

Oxcarbazepine versus phenytoin monotherapy for epilepsy: an individual participant data review 2018 · Cochrane Headline outcomes only
HR 1.04 [0.77, 1.41]
2 studies · 468 participants
Moderate

Intervention not reported

Tobacco use · children and young people aged 0 to 18 years

The intervention showed no clear difference in tobacco use (moderate certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 1.28 [0.75, 2.19]
2 studies · 521 participants
Moderate

Intervention not reported

Alcohol use · children and young people aged 0 to 18 years

The intervention showed no clear difference in alcohol use (moderate certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 0.8 [0.58, 1.11]
4 studies · 1911 participants
Moderate

Intervention not reported

Cannabis use · children and young people aged 0 to 18 years

The intervention showed no clear difference in cannabis use (moderate certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 0.69 [0.46, 1.04]
2 studies · 362 participants
Moderate

Intervention not reported

Illicit drug use · children and young people aged 0 to 18 years

The review found no eligible studies for this question.

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Antisocial behaviour · children and young people aged 0 to 18 years

The intervention showed no clear difference in antisocial behaviour (moderate certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 1.02 [0.62, 1.69]
1 study · 200 participants
Moderate

Intervention not reported

Sexual risk behaviour · children and young people aged 0 to 18 years

The intervention showed no clear difference in sexual risk behaviour (moderate certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 0.42 [0.14, 1.25]
1 study · 162 participants
Moderate

Intervention not reported

Physical activity · children and young people aged 0 to 18 years

The intervention showed no clear difference in physical activity (moderate certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 1.11 [0.74, 1.67]
2 studies · 1530 participants
Moderate

Intervention not reported

Tobacco use · children and young people aged 0 to 18 years

The intervention showed no clear difference in tobacco use (moderate certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 0.78 [0.4, 1.53]
2 studies · 313 participants
Moderate

Intervention not reported

Alcohol use · children and young people aged 0 to 18 years

The intervention showed no clear difference in alcohol use (moderate certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 0.83 [0.47, 1.46]
3 studies · 417 participants
Moderate

Intervention not reported

Cannabis use · children and young people aged 0 to 18 years

The intervention showed no clear difference in cannabis use (low certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 1.02 [0.52, 2.02]
3 studies · 380 participants
Low

Intervention not reported

Illicit drug use · children and young people aged 0 to 18 years

The intervention showed no clear difference in illicit drug use (moderate certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 0.74 [0.42, 1.31]
1 study · 69 participants
Moderate

Intervention not reported

Alcohol use · children and young people aged 0 to 18 years

The intervention showed no clear difference in alcohol use (moderate certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 1.02 [0.8, 1.31]
4 studies · 1204 participants
Moderate

Intervention not reported

Antisocial behaviour · children and young people aged 0 to 18 years

The intervention showed no clear difference in antisocial behaviour (moderate certainty).

1 finding from 1 review

Individual‐, family‐, and school‐level interventions targeting multiple risk behaviours in young people 2018 · Cochrane Headline outcomes only
OR 0.84 [0.57, 1.24]
5 studies · 772 participants
Moderate