Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

303 questions · 321 findings · 26 reviews · Gynaecology and Fertility

No studies found 64 · 19.9%GRADE not reported 3 · 0.9%Very low 67 · 20.9%Low 104 · 32.4%Moderate 77 · 24%High 6 · 1.9%

Presurgical medical therapy vs Placebo or no active treatment

Pain recurrence (dichotomous) Pain recurrence ≤ 12 months · women having endometriosis surgery

It is very uncertain whether presurgical medical therapy changes pain recurrence (dichotomous) Pain recurrence ≤ 12 months compared with placebo or no medical therapy (very low certainty).

1 finding from 1 review

Presurgical medical therapy vs Placebo or no active treatment

Disease recurrence ≤ 12 months (EEC stage) · women having endometriosis surgery

It is very uncertain whether presurgical medical therapy changes disease recurrence ≤ 12 months (EEC stage) compared with placebo or no medical therapy (very low certainty).

1 finding from 1 review

Postsurgical medical therapy vs Placebo or no active treatment

Pain recurrence (dichotomous) Pain recurrence ≤ 12 months · women having endometriosis surgery

Postsurgical medical therapy may leads to lower pain recurrence (dichotomous) Pain recurrence ≤ 12 months compared with placebo or no medical therapy (low certainty).

1 finding from 1 review

GnRHa treatment vs other medical therapies before any surgery

Preoperative bleeding: (PBAC < 75) ulipristal acetate 5 mg · women with uterine fibroids

GnRHa treatment showed no clear difference in preoperative bleeding: Reduction in bleeding to PBAC < 75 ulipristal… compared with other medical therapies before any surgery (moderate certainty).

1 finding from 1 review

GnRHa treatment vs other medical therapies before any surgery

Preoperative bleeding: Reduction in bleeding to PBAC < 75 ulipristal acetate 10 mg · women with uterine fibroids

GnRHa treatment showed no clear difference in preoperative bleeding: Reduction in bleeding to PBAC < 75 ulipristal… compared with other medical therapies before any surgery (moderate certainty).

1 finding from 1 review