Findings

What do systematic reviews say?

151 questions · 163 findings · 14 reviews · Pain, Palliative and Supportive Care

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No studies found 12 · 7.4%GRADE not reported 2 · 1.2%Very low 52 · 31.9%Low 52 · 31.9%Moderate 29 · 17.8%High 16 · 9.8%

Intervention not reported

Participants remedicating within 8 hours · Adults with acute pain

The intervention probably leads to lower participants remedicating within 8 hours (moderate certainty).

1 finding from 1 review

Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults 2015 · Cochrane Headline outcomes only
RR 0.5 [0.4, 0.6]
3 studies · 293 participants
Moderate

Intervention not reported

Participants with at least 1 adverse event · Adults with acute pain

The intervention showed no clear difference in participants with at least 1 adverse event (low certainty).

1 finding from 1 review

Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults 2015 · Cochrane Headline outcomes only
RR 1.9 [0.91, 3.8]
4 studies · 336 participants
Low

Intervention not reported

Participants with a serious adverse event · Adults with acute pain

1 finding from 1 review

Single dose oral ibuprofen plus caffeine for acute postoperative pain in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 336 participants
Low

Intervention not reported

At least 50% of maximum pain relief over 4 to 6 hours · adults with moderate or severe acute postoperative pain

The intervention leads to higher at least 50% of maximum pain relief over 4 to 6 hours (high certainty).

1 finding from 1 review

Single dose oral etoricoxib for acute postoperative pain in adults 2014 · Cochrane Headline outcomes only
RR 5.6 [4, 7.8]
Studies not reported
High

Intervention not reported

Participants with at least 1 adverse event · adults with moderate or severe acute postoperative pain

The intervention showed no clear difference in participants with at least 1 adverse event (moderate certainty).

1 finding from 1 review

Single dose oral etoricoxib for acute postoperative pain in adults 2014 · Cochrane Headline outcomes only
RR 0.93 [0.74, 1.2]
Studies not reported
Moderate

Intervention not reported

Participants with a serious adverse event · adults with moderate or severe acute postoperative pain

1 finding from 1 review

Single dose oral etoricoxib for acute postoperative pain in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

Deaths · adults with moderate or severe acute postoperative pain

1 finding from 1 review

Single dose oral etoricoxib for acute postoperative pain in adults 2014 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

At least 50% of maximum pain relief over 4 to 6 hours · Adults with moderate or severe acute postoperative pain

1 finding from 1 review

Single dose oral dexibuprofen [S(+)‐ibuprofen] for acute postoperative pain in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Participants with at least 1 adverse event · Adults with moderate or severe acute postoperative pain

1 finding from 1 review

Single dose oral dexibuprofen [S(+)‐ibuprofen] for acute postoperative pain in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Participants with a serious adverse event · Adults with moderate or severe acute postoperative pain

1 finding from 1 review

Single dose oral dexibuprofen [S(+)‐ibuprofen] for acute postoperative pain in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Deaths · Adults with moderate or severe acute postoperative pain

1 finding from 1 review

Single dose oral dexibuprofen [S(+)‐ibuprofen] for acute postoperative pain in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low