Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

162 questions · 167 findings · 24 reviews · Musculoskeletal

No studies found 65 · 38.9%GRADE not reported 6 · 3.6%Very low 24 · 14.4%Low 55 · 32.9%Moderate 16 · 9.6%High 1 · 0.6%

Benzbromarone vs probenecid

Withdrawals due to adverse events · people with chronic gout

Benzbromarone may leads to lower withdrawal due to adverse events compared with probenecid (low certainty).

1 finding from 1 review

Probenecid vs allopurinol

Acute gout attacks · people with chronic gout

Probenecid showed no clear difference in acute gout attacks compared with allopurinol (low certainty).

1 finding from 1 review

Probenecid vs allopurinol

Serum urate normalisation ≤ 5 mg/dL (≤ 0.3 mmol/L) ‐ not measured · people with chronic gout

The review found no eligible studies for this question.

1 finding from 1 review

Benzbromarone vs allopurinol

Serum urate normalisation ‐ not reported · people with chronic gout

Benzbromarone showed no clear difference in serum urate normalisation compared with allopurinol (moderate certainty).

1 finding from 1 review

Benzbromarone vs allopurinol

Withdrawals due to adverse events · people with chronic gout

Benzbromarone showed no clear difference in withdrawal due to adverse events compared with allopurinol (low certainty).

1 finding from 1 review