Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,368 questions · 1,413 findings · 89 reviews · Common Mental Disorders

No studies found 232 · 16.4%GRADE not reported 82 · 5.8%Very low 395 · 28%Low 331 · 23.4%Moderate 341 · 24.1%High 32 · 2.3%

Antipsychotics vs placebo

Clinical response of depression · adults with psychotic depression

It is very uncertain whether antipsychotic changes clinical response of depression compared with placebo (very low certainty).

1 finding from 1 review

n3PUFAs vs placebo

Depressive symptomology (continuous) HDRS where possible; higher scores indicate greater symptomology · adults with Major Depressive Disorder
1 finding from 1 review

n3PUFAs vs placebo

Depressive symptomology (dichotomous ‐ remission) Depressive symptomology rating scale as used by authors · adults with Major Depressive Disorder

n3PUFAs showed no clear difference in depressive symptomology (dichotomous ‐ remission)Depressive… compared with placebo (low certainty).

1 finding from 1 review

n3PUFAs vs placebo

Depressive symptomology (dichotomous ‐ response) Depressive symptomology rating scale as used by authors · adults with Major Depressive Disorder

n3PUFAs showed no clear difference in depressive symptomology (dichotomous ‐ response)Depressive… compared with placebo (low certainty).

1 finding from 1 review