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Evidence found and GRADE certainty

309 questions · 325 findings · 45 reviews · Acute Respiratory Infections

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No studies found 38 · 11.7%GRADE not reported 31 · 9.5%Very low 54 · 16.6%Low 78 · 24%Moderate 106 · 32.6%High 18 · 5.5%

Live zoster vaccine vs placebo

Participants with adverse events: 1 or more serious adverse events regardless of type of storage of the vaccine Clinical or laboratory criteria · healthy older adults aged ≥ 60 years

Live zoster vaccine showed no clear difference in participants with adverse events: 1 or more serious adverse events… compared with placebo (moderate certainty).

1 finding from 1 review

Live zoster vaccine vs placebo

Systemic adverse events at · healthy older adults aged ≥ 60 years

Live zoster vaccine showed no clear difference in participants with adverse events ‐ systemic adverse eventsClinical… compared with placebo (moderate certainty).

1 finding from 1 review

Live zoster vaccine vs placebo

Participants with adverse events ‐ injection site adverse events Clinical criteria · healthy older adults aged ≥ 60 years

Live zoster vaccine probably leads to higher participants with adverse events ‐ injection site adverse… compared with placebo (moderate certainty).

1 finding from 1 review

Live zoster vaccine vs placebo

Dropouts Clinical or laboratory criteria · healthy older adults aged ≥ 60 years

Live zoster vaccine showed no clear difference in dropoutsClinical or laboratory criteria compared with placebo (moderate certainty).

1 finding from 1 review

Recombinant zoster vaccine vs placebo

Cumulative incidence of herpes zoster at least 3.2 years · healthy older adults aged ≥ 60 years

Recombinant zoster vaccine probably leads to lower cumulative incidence of herpes zoster at least 3.2 years compared with placebo (moderate certainty).

1 finding from 1 review

Recombinant zoster vaccine vs placebo

Participants with adverse events ‐ death Clinical criteria · healthy older adults aged ≥ 60 years

Recombinant zoster vaccine showed no clear difference in participants with adverse events ‐ deathClinical criteria compared with placebo (moderate certainty).

1 finding from 1 review

Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care

Adverse events · children aged up to 16 years with ARTIs

It is very uncertain whether homeopathic medicinal products (non‐individualised treatment) changes adverse events compared with placebo or usual care (very low certainty).

1 finding from 1 review

Homeopathic medicinal products (individualised treatment) vs placebo or usual care

Recurrence of ARTI · children aged up to 16 years with ARTIs

Homeopathic medicinal products (individualised treatment) showed no clear difference in recurrence of ARTI compared with placebo or usual care (moderate certainty).

1 finding from 1 review

Homeopathic medicinal products (individualised treatment) vs placebo or usual care

Days off work for parents · children aged up to 16 years with ARTIs

Homeopathic medicinal products (individualised treatment) showed no clear difference in days off work for parents compared with placebo or usual care (moderate certainty).

1 finding from 1 review

Homeopathic medicinal products (individualised treatment) vs placebo or usual care

Need for antibiotics · children aged up to 16 years with ARTIs

Homeopathic medicinal products (individualised treatment) showed no clear difference in need for antibiotics compared with placebo or usual care (low certainty).

1 finding from 1 review

Homeopathic medicinal products (individualised treatment) vs placebo or usual care

Adverse events · children aged up to 16 years with ARTIs

Homeopathic medicinal products (individualised treatment) showed no clear difference in adverse events compared with placebo or usual care (moderate certainty).

1 finding from 1 review