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What do systematic reviews say?

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Evidence found and GRADE certainty

4,667 questions · 21,760 findings · 2,177 reviews

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No studies found 4,173 · 19.2%GRADE not reported 2,300 · 10.6%Very low 5,276 · 24.2%Low 5,764 · 26.5%Moderate 3,298 · 15.2%High 949 · 4.4%

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Antidepressants vs placebo

Physical function · predominantly knee osteoarthritis

Antidepressant showed no clear difference in mean change in physical function from baseline (0–100 WOMAC Total… compared with placebo (high certainty).

1 finding from 1 review

Antidepressants vs placebo

Quality of life (EuroQol, scale −0.11 to 1.0 where a score of 1.0 indicates perfect health) between 0 and 14 weeks · predominantly knee osteoarthritis

Antidepressant probably leads to higher quality of life (EuroQol, scale −0.11 to 1.0 where a score of 1.0… compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants vs placebo

Proportion of participants who withdrew due to adverse events between 0 and 14 weeks · predominantly knee osteoarthritis

Antidepressant probably leads to higher proportion of participants who withdrew due to adverse events… compared with placebo (moderate certainty).

1 finding from 1 review

Antidepressants vs placebo

Total adverse events between 0 and 16 weeks · predominantly knee osteoarthritis

Antidepressant leads to higher total adverse events between 0 and 16 weeks compared with placebo (high certainty).

1 finding from 1 review

Antidepressants vs placebo

Serious adverse events between 0 and 16 weeks · predominantly knee osteoarthritis

Antidepressant showed no clear difference in serious adverse events between 0 and 16 weeks compared with placebo (low certainty).

1 finding from 1 review

TCAs with predominantly SRI actions vs placebo

Clinical Global Impressions scale change item (CGI‐I): no. of responders (long term) Post‐treatment: 1‐4 months · adults with trichotillomania

It is very uncertain whether TCAs with predominantly SRI actions changes treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (very low certainty).

1 finding from 1 review

Prehabilitation vs no prehabilitation

Complications within 30 days postoperatively · Patients with outcomes after colorectal cancer surgery

Prehabilitation showed no clear difference in complications within 30 days postoperatively compared with no prehabilitation (low certainty).

1 finding from 1 review