Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

241 questions · 264 findings · 24 reviews

No studies found 84 · 31.8%GRADE not reported 5 · 1.9%Very low 83 · 31.4%Low 64 · 24.2%Moderate 21 · 8%High 7 · 2.7%

Full or partial opioid agonist maintenance vs placebo, detoxification only or psychological treatment (buprenorphine maintenance compared to taper or treatment

Adverse events · pharmaceutical opioid dependent people

It is very uncertain whether full or partial opioid agonist maintenance changes adverse events compared with placebo, detoxification only or psychological treatment… (very low certainty).

1 finding from 1 review

Full or partial opioid agonist maintenance vs placebo, detoxification only or psychological treatment (buprenorphine maintenance compared to taper or treatment

Days of unsanctioned opioid use · pharmaceutical opioid dependent people

Full or partial opioid agonist maintenance showed no clear difference in days of unsanctioned opioid use (as number of days/30 or days/7) compared with placebo, detoxification only or psychological treatment… (low certainty).

1 finding from 1 review

Full or partial opioid agonist maintenance vs placebo, detoxification only or psychological treatment (buprenorphine maintenance compared to taper or treatment

Opioid use · pharmaceutical opioid dependent people

It is very uncertain whether full or partial opioid agonist maintenance changes self‐reported opioid use at treatment completion compared with placebo, detoxification only or psychological treatment… (very low certainty).

2 findings from 1 review

Full or partial opioid agonist maintenance vs placebo, detoxification only or psychological treatment (buprenorphine maintenance compared to taper or treatment

Retention in treatment · pharmaceutical opioid dependent people

Full or partial opioid agonist maintenance probably leads to higher retention: proportion of participants retained in treatment compared with placebo, detoxification only or psychological treatment… (moderate certainty).

1 finding from 1 review

Morphine vs fentanyl

Neurodevelopmental outcomes · neonates with mechanical ventilation

The review found no eligible studies for this question.

3 findings from 1 review