Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

510 questions · 533 findings · 60 reviews

No studies found 153 · 28.7%GRADE not reported 18 · 3.4%Very low 134 · 25.1%Low 123 · 23.1%Moderate 80 · 15%High 25 · 4.7%

Systemic tranexamic acid vs control

Short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment · people with traumatic hyphema

Systemic tranexamic acid showed no clear difference in short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment compared with control (moderate certainty).

1 finding from 1 review

Systemic aminocaproic acid vs placebo

Long‐term visual acuity 20/40 or better > 2 months after treatment · people with traumatic hyphema

Systemic aminocaproic acid showed no clear difference in long‐term visual acuity 20/40 or better > 2 months after treatment compared with placebo (low certainty).

1 finding from 1 review

Non‐pharmaceutical interventions vs control

Visual acuity · people with traumatic hyphema

Non‐pharmaceutical interventions showed no clear difference in short‐term visual acuity between 20/20 and 20/60 at end of… compared with control (low certainty).

2 findings from 1 review

Non‐pharmaceutical interventions vs control

Risk of secondary hemorrhage; ambulatory treatment versus bed rest · people with traumatic hyphema

Non‐pharmaceutical interventions showed no clear difference in risk of secondary hemorrhage; ambulatory treatment vs bed rest compared with control (low certainty).

1 finding from 1 review

Topical aminocaproic acid vs placebo

Short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment · people with traumatic hyphema

Topical aminocaproic acid showed no clear difference in short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment compared with placebo (low certainty).

1 finding from 1 review

Decompressive craniectomy vs medical treatment

Mortality at 6 months · patients > 12 months of age with a severe traumatic brain injury and in a coma (post‐resuscitation GOS score ≤ 8 points) with raised,…

Decompressive craniectomy probably leads to lower mortality at 6 months compared with medical treatment only (moderate certainty).

1 finding from 1 review

Decompressive craniectomy vs medical treatment

Mortality at 12 months · patients > 12 months of age with a severe traumatic brain injury and in a coma (post‐resuscitation GOS score ≤ 8 points) with raised,…

Decompressive craniectomy leads to lower mortality at 12 months compared with medical treatment only (high certainty).

1 finding from 1 review

Decompressive craniectomy vs medical treatment

'Unfavorable outcome' as per original Cochrane protocol at 6 months · patients > 12 months of age with a severe traumatic brain injury and in a coma (post‐resuscitation GOS score ≤ 8 points) with raised,…

Decompressive craniectomy may leads to higher 'Unfavorable outcome' as per original Cochrane protocol at 6 months compared with medical treatment only (low certainty).

1 finding from 1 review

Decompressive craniectomy vs medical treatment

'Unfavorable outcome' as per original Cochrane protocol ‐ at 12 months · patients > 12 months of age with a severe traumatic brain injury and in a coma (post‐resuscitation GOS score ≤ 8 points) with raised,…

Decompressive craniectomy showed no clear difference in 'Unfavorable outcome' as per original Cochrane protocol ‐ at 12 months compared with medical treatment only (high certainty).

1 finding from 1 review

Decompressive craniectomy vs medical treatment

Changes in ICP from randomization up to 48 h · patients > 12 months of age with a severe traumatic brain injury and in a coma (post‐resuscitation GOS score ≤ 8 points) with raised,…

Decompressive craniectomy showed no clear difference in changes in ICP from randomization up to 48 h compared with medical treatment only (moderate certainty).

1 finding from 1 review

Sedation

Outcome not reported · Medically compromised children (ASA III+) or children with learning/behavioural difficulties needing dental treatment

The review found no eligible studies for this question.

1 finding from 1 review
  • 'Some of the techniques described may be useful in the management of medically compromised patients, but at present there are no studies carried out in these groups.' (Discussion) Explicit evidence gap.
    0 studies
    No studies found