Dental caries (by severity) · Children or adolescents
One study reported higher median caries severity among CLWH under 12 years; no meta-analytic estimate was pooled.
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
Low-level laser therapy (LLLT) showed no clear difference in radiological failure compared with calcium hydroxide (CH); GRADE not reported.
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
Low-level laser therapy (LLLT) showed no clear difference in radiological failure compared with formocresol (FC); GRADE not reported.
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
Low-level laser therapy (LLLT) + calcium hydroxide showed no clear difference in radiological failure compared with formocresol (FC); GRADE not reported.
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
Low-level laser therapy (LLLT) + calcium hydroxide showed no clear difference in radiological failure compared with calcium hydroxide (CH); GRADE not reported.
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
High salivary S. mutans (over 10^4 CFU/ml) · Periodontitis patients
High-level S. mutans did not change significantly after periodontal therapy (OR 1.54).
1 finding from 1 review
Caries increment on permanent tooth surfaces (D(M)FS), prevented fraction · Children and adolescents aged 16 years or younger (permanent dentition)
7 findings from 1 review
Show 4 more findings
PF 0.28 [0.19, 0.37]
22 studies
GRADE not reported
PF 0.40 [0.31, 0.49]
17 studies
GRADE not reported
PF 0.24 [0.21, 0.28]
70 studies
GRADE not reported
PF 0.46 [0.30, 0.63]
7 studies
GRADE not reported
Caries increment on primary (deciduous) tooth surfaces (d(e/m)fs), prevented fraction · Children with primary (deciduous) teeth (younger children)
5 findings from 1 review
PF 0.26 [-0.11, 0.63]
2 studies
GRADE not reported
PF 0.41 [0.26, 0.55]
2 studies
GRADE not reported
PF 0.27 [0.08, 0.48]
3 studies
GRADE not reported
Show 2 more findings
PF 0.33 [0.22, 0.44]
5 studies
GRADE not reported
PF 0.33 [0.19, 0.48]
3 studies
GRADE not reported
Caries increment on permanent whole teeth (D(M)FT), prevented fraction · Children and adolescents aged 16 years or younger (permanent dentition)
7 findings from 1 review
PF 0.26 [0.21, 0.30]
79 studies
GRADE not reported
PF 0.53 [0.23, 0.82]
3 studies
GRADE not reported
PF 0.32 [0.19, 0.46]
10 studies
GRADE not reported
Show 4 more findings
PF 0.45 [0.32, 0.58]
7 studies
GRADE not reported
PF 0.24 [0.18, 0.30]
13 studies
GRADE not reported
PF 0.24 [0.20, 0.28]
72 studies
GRADE not reported
PF 0.23 [0.19, 0.28]
53 studies
GRADE not reported
Adverse effects (tooth staining/discoloration, oral soft-tissue signs, adverse symptoms such as nausea/vomiting, enamel etching) · Children and adolescents aged 16 years or less
1 finding from 1 review
Data on adverse effects (stain score, proportion of children with tooth staining, signs of sensitivity in oral soft tissue, adverse symptoms such as nausea/vomiting, etching of enamel) were reported in only a few…
Studies not reported
GRADE not reported
Adverse effects: dental fluorosis · Children and adolescents aged 16 years or less
The review found no eligible studies for this question.
1 finding from 1 review
Unacceptability of treatment (dropouts/exclusions during the trial) · Children and adolescents aged 16 years or less
Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish;… showed no clear difference in unacceptability of treatment (dropouts/exclusions during the trial) compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
RR 1.20 [0.85, 1.70]
10 studies
GRADE not reported
Proportion developing new caries · Children and adolescents aged 16 years or younger (permanent dentition)
Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish;… led to lower proportion of children developing one or more new caries compared with placebo or no treatment; GRADE not reported.
1 finding from 1 review
RR 0.88 [0.82, 0.95]
13 studies
GRADE not reported
Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…
It is very uncertain whether non-selective carious tissue removal and conventional restoration (CR) changes failure of therapy compared with selective carious tissue removal (selective excavation, SE) (very low certainty).
3 findings from 1 review
Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…
It is very uncertain whether sealing using sealant materials changes failure of therapy compared with selective carious tissue removal (selective excavation, SE) (very low certainty).
1 finding from 1 review
Failure of therapy · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…
Non-selective carious tissue removal and conventional restoration (CR) probably leads to higher failure of therapy compared with stepwise carious tissue removal (SW) (moderate certainty).
2 findings from 1 review