Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

460 questions · 464 findings · 50 reviews · Pregnancy and Childbirth

No studies found 103 · 22.2%GRADE not reported 61 · 13.1%Very low 120 · 25.9%Low 112 · 24.1%Moderate 59 · 12.7%High 9 · 1.9%

External uterine compression (all methods) plus normal care vs normal care

Mortality due to bleeding ‐ not reported · women diagnosed with primary PPH following vaginal birth. PPH was defined as quote: "blood loss > 500mL after delivery" p 601

The review found no eligible studies for this question.

1 finding from 1 review

External uterine compression (all methods) plus normal care vs normal care

Serious maternal morbidity (renal or respiratory failure, cardiac arrest or multiple organ failure) ‐ not reported · women diagnosed with primary PPH following vaginal birth. PPH was defined as quote: "blood loss > 500mL after delivery" p 601

The review found no eligible studies for this question.

1 finding from 1 review

External uterine compression (all methods) plus normal care vs normal care

Blood transfusion (red cell or whole blood) · women diagnosed with primary PPH following vaginal birth. PPH was defined as quote: "blood loss > 500mL after delivery" p 601

It is very uncertain whether external uterine compression (all methods) plus normal care changes blood transfusion (red cell or whole blood) compared with normal care (very low certainty).

1 finding from 1 review

External uterine compression (all methods) plus normal care vs normal care

Side effects of the intervention (e.g. trauma, necrosis) ‐ not reported · women diagnosed with primary PPH following vaginal birth. PPH was defined as quote: "blood loss > 500mL after delivery" p 601

The review found no eligible studies for this question.

1 finding from 1 review

Multiple methods of breastfeeding support (including social, educational and/or physical support) vs usual care

Breastfeeding · pregnant or lactating women who were overweight or obese

It is very uncertain whether multiple methods of breastfeeding support (including social,… changes any breastfeeding at 6 months compared with usual care (very low certainty).

2 findings from 1 review

Multiple methods of breastfeeding support (including social, educational and/or physical support) vs usual care

Non‐initiation of breastfeeding · pregnant or lactating women who were overweight or obese

It is very uncertain whether multiple methods of breastfeeding support (including social,… changes non‐initiation of breastfeeding compared with usual care (very low certainty).

1 finding from 1 review

Multiple methods of breastfeeding support (including social, educational and/or physical support) vs usual care

Exclusive breastfeeding at 4‐6 weeks · pregnant or lactating women who were overweight or obese

It is very uncertain whether multiple methods of breastfeeding support (including social,… changes exclusive breastfeeding at 4‐6 weeks compared with usual care (very low certainty).

1 finding from 1 review

Multiple methods of breastfeeding support (including social, educational and/or physical support) vs usual care

Exclusive breastfeeding at 6 months · pregnant or lactating women who were overweight or obese

It is very uncertain whether multiple methods of breastfeeding support (including social,… changes exclusive breastfeeding at 6 months compared with usual care (very low certainty).

1 finding from 1 review

Antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) vs broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all outcomes

Endometritis · women undergoing caesarean section

Antistaphylococcal cephalosporins C1 and C2 (1st and 2nd generation) showed no clear difference in maternal endometritis compared with broad spectrum penicillins plus betalactamase inhibitors P2+ ‐ all… (low certainty).

1 finding from 1 review

Vaginal preparation with antiseptic solution vs control (no preparation or saline preparation)

Post‐cesarean endometritis · pregnant women undergoing caesarean section

Vaginal preparation with antiseptic solution probably leads to lower post‐cesarean endometritis compared with control (no preparation or saline preparation) (moderate certainty).

1 finding from 1 review

Vaginal preparation with antiseptic solution vs control (no preparation or saline preparation)

Composite wound complication or endometritis · pregnant women undergoing caesarean section

Vaginal preparation with antiseptic solution may leads to lower composite wound complication or endometritis compared with control (no preparation or saline preparation) (low certainty).

1 finding from 1 review

Oral magnesium vs placebo/no treatment

Duration of leg cramps: persisting symptoms after night‐time cramps Sometimes · treating leg cramps in pregnancy

It is very uncertain whether oral magnesium changes duration of leg cramps: persisting symptoms after night‐time cramps… compared with placebo/no treatment (very low certainty).

1 finding from 1 review