Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

720 questions · 751 findings · 105 reviews

No studies found 193 · 25.7%GRADE not reported 37 · 4.9%Very low 212 · 28.2%Low 193 · 25.7%Moderate 99 · 13.2%High 17 · 2.3%

Injectional nicardipine vs Normal saline

Treatment‐related adverse effects · men with chronic Peyronie's disease (plaques without calcification)

It is very uncertain whether injectional nicardipine changes treatment‐related adverse effects compared with saline (very low certainty).

1 finding from 1 review

Injectional collagenase vs placebo

Outcomes ( · men with Peyronie's disease (diagnosis of disease: at least 12 months, penile curvature: at least 30 degrees)

The review found no eligible studies for this question.

2 findings from 1 review

Injectional collagenase vs placebo

Patient‐reported ability to have intercourse · men with Peyronie's disease (diagnosis of disease: at least 12 months, penile curvature: at least 30 degrees)

The review found no eligible studies for this question.

2 findings from 1 review

Injectional collagenase vs placebo

Treatment‐related adverse effects · men with Peyronie's disease (diagnosis of disease: at least 12 months, penile curvature: at least 30 degrees)

The review found no eligible studies for this question.

2 findings from 1 review

Injectional collagenase vs placebo

Treatment discontinuation · men with Peyronie's disease (diagnosis of disease: at least 12 months, penile curvature: at least 30 degrees)

The review found no eligible studies for this question.

2 findings from 1 review

Local corticosteroid injection (LCI) vs a control strategy (no treatment, placebo or waiting list controls)

Heel pain: VAS 0 to 100 (higher scores = worse pain) ‐ short‐term · Adults with plantar heel pain¹

Local steroid injection showed no clear difference in heel pain: VAS 0 to 100 (higher scores = worse pain) ‐ short‐term compared with placebo or no treatment control (low certainty).

1 finding from 1 review

Local corticosteroid injection (LCI) vs a control strategy (no treatment, placebo or waiting list controls)

Heel pain: VAS 0 to 100 (higher scores = worse pain) ‐ medium‐term · Adults with plantar heel pain¹

Local steroid injection showed no clear difference in heel pain: VAS 0 to 100 (higher scores = worse pain) ‐ medium‐term compared with placebo or no treatment control (low certainty).

1 finding from 1 review

Local corticosteroid injection (LCI) vs a control strategy (no treatment, placebo or waiting list controls)

Function: medium‐term FFI (0 to 100: higher scores = worse function) FHSQ (0 to 100: higher scores = better function · Adults with plantar heel pain¹

It is very uncertain whether local steroid injection changes function: medium‐term FFI (0 to 100: higher scores = worse function)… compared with placebo or no treatment control (very low certainty).

1 finding from 1 review

Local corticosteroid injection (LCI) vs a control strategy (no treatment, placebo or waiting list controls)

Treatment failure (Heel pain persists at 8 weeks; subsequent treatment at 12 weeks; no pain relief at 6 months) · Adults with plantar heel pain¹

It is very uncertain whether local steroid injection changes treatment failure (Heel pain persists at 8 weeks; subsequent… compared with placebo or no treatment control (very low certainty).

1 finding from 1 review