Findings

What do systematic reviews say?

217 questions · 227 findings · 49 reviews · Schizophrenia

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No studies found 5 · 2.2%GRADE not reported 12 · 5.3%Very low 105 · 46.3%Low 46 · 20.3%Moderate 57 · 25.1%High 2 · 0.9%

RISPERIDONE DEPOT vs ARIPIPRAZOLE

Clinical response: mean score/change in mental state: mean PANSS total score (high = poor) · patients with schizophrenia

1 finding from 1 review

Risperidone (depot) for schizophrenia 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 349 participants
Low

RISPERIDONE DEPOT vs OLANZAPINE

Clinical response: mean score/change in mental state: mean PANSS total score (high = poor) · patients with schizophrenia

1 finding from 1 review

Risperidone (depot) for schizophrenia 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 361 participants
Low

RISPERIDONE DEPOT vs TYPICAL DEPOT ANTIPSYCHOTICS

Clinical response: mean score/change in mental state: mean PANSS total score (high = poor) · patients with schizophrenia

1 finding from 1 review

Risperidone (depot) for schizophrenia 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 43 participants
Low

Active education + Support for implementation vs Routine care or Passive dissemination

Patient outcome: Global state: average score (PANSS total, high = poor) · patients with schizophrenia or related psychoses

1 finding from 1 review

Implementation of treatment guidelines for specialist mental health care 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 59 participants
Very low

Active education + Support for implementation vs Routine care or Passive dissemination

Patient outcome: satisfaction with care: average score (ZUF8, high = better satisfaction) · patients with schizophrenia or related psychoses

1 finding from 1 review

Implementation of treatment guidelines for specialist mental health care 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 46 participants
Very low

Active education + Support for implementation vs Routine care or Passive dissemination

Drug attitude—DAI · patients with schizophrenia or related psychoses

1 finding from 1 review

Implementation of treatment guidelines for specialist mental health care 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 32 participants
Very low

CHLORPROMAZINE vs RISPERIDONE

QoL · patients with schizophrenia

1 finding from 1 review

Chlorpromazine versus atypical antipsychotic drugs for schizophrenia 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 100 participants
Very low

CHLORPROMAZINE vs QUETIAPINE

Mental state: psychopathology Total endpoint data, BPRS (higher score = worse, scale from: 0‐126) · patients with schizophrenia

1 finding from 1 review

Chlorpromazine versus atypical antipsychotic drugs for schizophrenia 2016 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 548 participants
Very low

CHLORPROMAZINE vs QUETIAPINE

Quality of life: 1a. Average endpoint scores on various scales (MSQoL‐54, high = good) ‐ short term · patients with schizophrenia

1 finding from 1 review

Chlorpromazine versus atypical antipsychotic drugs for schizophrenia 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 59 participants
Very low

CHLORPROMAZINE vs OLANZAPINE

Mental state: General ‐ average endpoint score (BPRS, high score = poor) ‐ medium term ( · patients with schizophrenia

1 finding from 1 review

Chlorpromazine versus atypical antipsychotic drugs for schizophrenia 2016 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 245 participants
Very low

CHLORPROMAZINE vs OLANZAPINE

Health‐related quality of life (physical) · patients with schizophrenia

1 finding from 1 review

Chlorpromazine versus atypical antipsychotic drugs for schizophrenia 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 61 participants
Very low

CHLORPROMAZINE vs RISPERIDONE

Mental state: psychopathology Total endpoint data, BPRS (higher score = worse, scale from: 0‐126) · patients with schizophrenia

1 finding from 1 review

Chlorpromazine versus atypical antipsychotic drugs for schizophrenia 2016 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 247 participants
Very low

FLUPHENAZINE (ORAL) vs AMISULPRIDE

Mental state · patients with schizophrenia

1 finding from 1 review

Fluphenazine (oral) versus atypical antipsychotics for schizophrenia 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 57 participants
Very low

ANY FORM OF PSYCHOEDUCATION vs usual care

Siblings' quality of life ‐ by 12 months (reversed FAD, high = good) Reversed FAD. Scale from: 4 to 28. · Siblings of people with severe mental illness

1 finding from 1 review

Psychoeducation for siblings of people with severe mental illness 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 9 participants
Low

ANY FORM OF PSYCHOEDUCATION vs usual care

Siblings' coping (in terms of burden) ‐ by 12 months (FBIS, high = poor) · Siblings of people with severe mental illness

1 finding from 1 review

Psychoeducation for siblings of people with severe mental illness 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 9 participants
Low

ANY FORM OF PSYCHOEDUCATION vs usual care

Mental state · Siblings of people with severe mental illness

1 finding from 1 review

Psychoeducation for siblings of people with severe mental illness 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 9 participants
Low

ANY FORM OF PSYCHOEDUCATION vs usual care

Social functioning · Siblings of people with severe mental illness

1 finding from 1 review

Psychoeducation for siblings of people with severe mental illness 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 9 participants
Low

ANY FORM OF BRIEF PSYCHOEDUCATION vs CBT

Mental state: 2. Positive symptoms ‐ average endpoint score PANSS positive subscore · people with severe mental disorders

1 finding from 1 review

Psychoeducation (brief) for people with serious mental illness 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 88 participants
Very low

ANY FORM OF BRIEF PSYCHOEDUCATION vs CBT

Quality of life: 1a. Average endpoint scores on various scales (MSQoL‐54, high = good) ‐ short term · people with severe mental disorders

1 finding from 1 review

Psychoeducation (brief) for people with serious mental illness 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 63 participants
Very low

ANY FORM OF BRIEF PSYCHOEDUCATION vs usual care

Global state Global Assessment Scale (GAS) · people with serious mental illness

1 finding from 1 review

Psychoeducation (brief) for people with serious mental illness 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 101 participants
Very low