Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between G allele vs A allele of LTF rs1126478 and dental caries susceptibility (G vs A model: OR 0.98, 95% CI 0.87-1.10); certainty not graded.
5 findings from 1 review
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Dental caries susceptibility · Ethnicity: Caucasian (n=2) individuals with caries/high caries and controls
The pooled odds ratio was 0.73 (95% CI 0.19 to 2.87).
1 finding from 1 review
OR 0.73 [0.19, 2.87]
2 studies
GRADE not reported
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between T allele vs C allele of AMELX rs17878486 and dental caries susceptibility (T vs C model: OR 2.87, 95% CI 0.35-23.23) in the Control group: Caries-free subgroup; certainty not graded.
8 findings from 1 review
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Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between CT genotype vs CC genotype of AMELX rs2106416 and dental caries susceptibility (CT vs CC model: OR 1.20, 95% CI 0.65-2.22) in the Ethnicity: Caucasian subgroup; certainty not graded.
3 findings from 1 review
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between GG genotype vs AA + AG genotype of ENAM rs1264848 and dental caries susceptibility (GG vs AA + AG model: OR 1.09, 95% CI 0.53-2.23) in the Ethnicity: Mixed subgroup; certainty not graded.
6 findings from 1 review
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Dental caries susceptibility · Ethnicity: Asian (n=1) individuals with caries/high caries and controls
The pooled odds ratio was 1.38 (95% CI 0.25 to 7.75).
1 finding from 1 review
OR 1.38 [0.25, 7.75]
1 study
GRADE not reported
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
The pooled odds ratio was 0.55 (95% CI 0.13 to 2.25).
1 finding from 1 review
Dental caries susceptibility · Age group: Children (n=4) individuals with caries/high caries and controls
The pooled odds ratio was 0.95 (95% CI 0.80 to 1.13).
1 finding from 1 review
OR 0.95 [0.80, 1.13]
4 studies
GRADE not reported
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between TT genotype vs CC + CT genotype of AMELX rs2106416 and dental caries susceptibility (TT vs CC + CT model: OR 1.67, 95% CI 0.44-6.34) in the Ethnicity: Caucasian subgroup; certainty not graded.
3 findings from 1 review
Dental caries susceptibility · Ethnicity: Caucasian (n=2) individuals with caries/high caries and controls
The pooled odds ratio was 2.03 (95% CI 0.10 to 42.44).
1 finding from 1 review
OR 2.03 [0.10, 42.44]
2 studies
GRADE not reported
Dental caries susceptibility · Ethnicity: Caucasian (n=1) individuals with caries/high caries and controls
The pooled odds ratio was 1.27 (95% CI 0.49 to 3.30).
1 finding from 1 review
OR 1.27 [0.49, 3.30]
1 study
GRADE not reported
Dental caries susceptibility · Ethnicity: Asian (n=2) individuals with caries/high caries and controls
The pooled odds ratio was 0.89 (95% CI 0.23 to 3.48).
1 finding from 1 review
OR 0.89 [0.23, 3.48]
2 studies
GRADE not reported
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between AG + GG genotype (G-allele carriers) vs AA genotype of ENAM rs1264848 and dental caries susceptibility (AG + GG vs AA model: OR 1.69, 95% CI 0.78-3.68) in the Ethnicity: Mixed subgroup; certainty not graded.
6 findings from 1 review
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Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between TT genotype vs CC + CT genotype of AMELX rs946252 and dental caries susceptibility (TT vs CC + CT model: OR 0.73, 95% CI 0.19-2.87) in the Control group: Caries-free subgroup; certainty not graded.
6 findings from 1 review
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Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between T allele vs C allele of AMELX rs6639060 and dental caries susceptibility (T vs C model: OR 1.08, 95% CI 0.63-1.85) in the Ethnicity: Caucasian subgroup; certainty not graded.
3 findings from 1 review
Salivary function impairment (buffering capacity, flow rate, oral pH) · Adults with gastroesophageal reflux disease (GERD) or laryngopharyngeal reflux (LPR)
Reflux is associated with impaired salivary function (notably reduced buffering capacity) as a proposed pathophysiological mechanism, based on several ungraded studies.
1 finding from 1 review
Mixed/controversial salivary findings: reduced salivary buffering capacity supported in three studies (Correa, Holbrook, Filipi) with low oral pH and reduced flow as additional factors in GERD patients, but Meurman and Schroeder found no significant salivary abnormalities; no pooled estimate.
6 studies
GRADE not reported
Dental caries susceptibility · Age group: Children (n=4) individuals with caries/high caries and controls
The pooled odds ratio was 0.99 (95% CI 0.81 to 1.23).
1 finding from 1 review
OR 0.99 [0.81, 1.23]
4 studies
GRADE not reported
Dental caries susceptibility · Ethnicity: Asian (n=2) individuals with caries/high caries and controls
The pooled odds ratio was 0.92 (95% CI 0.24 to 3.58).
1 finding from 1 review
OR 0.92 [0.24, 3.58]
2 studies
GRADE not reported
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between TT genotype vs CC genotype of AMELX rs2106416 and dental caries susceptibility (TT vs CC model: OR 1.83, 95% CI 0.47-7.06); certainty not graded.
3 findings from 1 review
Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)
No significant association between TT genotype vs CC + CT genotype of ENAM rs3796703 and dental caries susceptibility (TT vs CC + CT model: OR 2.90, 95% CI 0.92-9.12); certainty not graded.
3 findings from 1 review