Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

202 questions · 203 findings · 28 reviews · Haematology

No studies found 46 · 22.7%GRADE not reported 14 · 6.9%Very low 31 · 15.3%Low 68 · 33.5%Moderate 34 · 16.7%High 10 · 4.9%

Prophylactic platelet transfusion prior to surgery vs no prophylactic platelet transfusion prior to surgery

Number of participants with major bleeding within 7 days of surgery (surgical site bleeding requiring a second intervention or reoperation or surgical site bleeding that causes a haematoma or haemarthrosis of sufficient size to delay mobilisation ... · people with a low platelet count

It is very uncertain whether prophylactic platelet transfusion prior to surgery changes number of participants with major bleeding within 7 days of surgery… compared with no prophylactic platelet transfusion prior to surgery (very low certainty).

1 finding from 1 review

Prophylactic platelet transfusion prior to surgery vs no prophylactic platelet transfusion prior to surgery

Number of participants with minor procedure‐related bleeding within 7 days of surgery · people with a low platelet count

It is very uncertain whether prophylactic platelet transfusion prior to surgery changes the number of participants with minor procedure‐related bleeding… compared with no prophylactic platelet transfusion prior to surgery (very low certainty).

1 finding from 1 review

Recombinant human soluble thrombomodulin vs heparin

Mortality from any cause (15‐day and 30‐day in‐hospital) · DIC

It is very uncertain whether recombinant human soluble thrombomodulin changes mortality from any cause (15‐day and 30‐day in‐hospital) compared with heparin (very low certainty).

1 finding from 1 review