Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

249 questions · 262 findings · 42 reviews · All outcomes

No studies found 35 · 13.4%GRADE not reported 144 · 55%Very low 60 · 22.9%Low 21 · 8%Moderate 2 · 0.8%High 0 · 0%

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Number of days of treatment with opioid analgesics · Adults with cancer receiving treatment

Keratinocyte growth factor (KGF; palifermin or repifermin),… showed no clear difference in number of days of treatment with opioid analgesics compared with placebo; GRADE not reported.

1 finding from 1 review

Papilla base incision (PBI) vs Complete papilla mobilisation (sulcular incision)

Postoperative pain (VAS 0-100) - 3 days · People requiring retreatment of periapical lesions (failed root canal therapy)

Papilla base incision (PBI) led to lower postoperative pain (VAS 0-100) - 3 days compared with complete papilla mobilisation (sulcular incision); GRADE not reported.

1 finding from 1 review

Monitoring (any means of observation, supervision, keeping under review, measuring or testing at intervals) vs No monitoring

Oral health: Not brushing teeth twice a day · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

The review found no eligible studies for this question.

1 finding from 1 review

Educational intervention with information and practical components (theoretical oral health education plus practical skills training) for nursing staff and/or residents vs usual care

Oral health: Not brushing teeth twice a day · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

The review found no eligible studies for this question.

1 finding from 1 review

Mineral trioxide aggregate (MTA) root-end filling vs Intermediate restorative material (IRM)

Prevalence of pain - 1 day · People requiring retreatment of periapical lesions (failed root canal therapy)

Mineral trioxide aggregate (MTA) root-end filling showed no clear difference in prevalence of pain - 1 day compared with intermediate restorative material (IRM) (low certainty).

1 finding from 1 review

Papilla base incision (PBI) vs Complete papilla mobilisation (sulcular incision)

Postoperative pain (VAS 0-100) - 2 days · People requiring retreatment of periapical lesions (failed root canal therapy)

Papilla base incision (PBI) showed no clear difference in postoperative pain (VAS 0-100) - 2 days compared with complete papilla mobilisation (sulcular incision); GRADE not reported.

1 finding from 1 review

Papilla base incision (PBI) vs Complete papilla mobilisation (sulcular incision)

Postoperative pain (VAS 0-100) - 1 day · People requiring retreatment of periapical lesions (failed root canal therapy)

It is very uncertain whether papilla base incision (PBI) changes postoperative pain (VAS 0-100) - 1 day compared with complete papilla mobilisation (sulcular incision) (very low certainty).

1 finding from 1 review

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Daytime symptom: thirstiness in the morning (questionnaire) · Children with obstructive sleep apnoea (aged 15 years or younger)

Oral appliance or functional orthopaedic appliance showed no clear difference in daytime symptom: thirstiness in the morning (questionnaire) compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Tiredness · Children with obstructive sleep apnoea (aged 15 years or younger)

It is very uncertain whether oral appliance or functional orthopaedic appliance changes daytime symptom: tiredness (Brouillette questionnaire) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Daytime symptom: sleepiness (Brouillette questionnaire) · Children with obstructive sleep apnoea (aged 15 years or younger)

It is very uncertain whether oral appliance or functional orthopaedic appliance changes daytime symptom: sleepiness (Brouillette questionnaire) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Irritability · Children with obstructive sleep apnoea (aged 15 years or younger)

It is very uncertain whether oral appliance or functional orthopaedic appliance changes daytime symptom: irritability (Brouillette questionnaire) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Daytime symptom: morning headache (Brouillette questionnaire) · Children with obstructive sleep apnoea (aged 15 years or younger)

It is very uncertain whether oral appliance or functional orthopaedic appliance changes daytime symptom: morning headache (Brouillette questionnaire) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Mineral trioxide aggregate (MTA) root-end filling vs Gutta-percha smoothing (orthograde GP root filling)

Postoperative pain (VAS 0-100) - 1 day · People requiring retreatment of periapical lesions (failed root canal therapy)

Mineral trioxide aggregate (MTA) root-end filling showed no clear difference in postoperative pain (VAS 0-100) - 1 day compared with gutta-percha smoothing (orthograde GP root filling) (low certainty).

1 finding from 1 review

Motivational interview plus oral health education vs Oral health education

Oral health: Not brushing teeth twice a day · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

The review found no eligible studies for this question.

1 finding from 1 review

Root-end resection (with or without root-end filling; surgical retreatment) vs Non-surgical re-treatment (orthograde root canal therapy)

Prevalence of pain - 1 day · People with one or more endodontically treated teeth and a periapical condition requiring retreatment

Root-end resection (with or without root-end filling; surgical… may leads to higher prevalence of pain - 1 day (participants reporting pain) compared with root canal retreatment (non-surgical/orthograde) (low certainty).

1 finding from 1 review

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Daytime symptom: oral breathing (questionnaire) · Children with obstructive sleep apnoea (aged 15 years or younger)

It is very uncertain whether oral appliance or functional orthopaedic appliance changes daytime symptom: oral breathing (questionnaire) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Daytime symptom: nasal stuffiness (questionnaire) · Children with obstructive sleep apnoea (aged 15 years or younger)

It is very uncertain whether oral appliance or functional orthopaedic appliance changes daytime symptom: nasal stuffiness (questionnaire) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Oral appliance or functional orthopaedic appliance vs placebo or no treatment

Daytime symptom: school problems (Brouillette questionnaire) · Children with obstructive sleep apnoea (aged 15 years or younger)

It is very uncertain whether oral appliance or functional orthopaedic appliance changes daytime symptom: school problems (Brouillette questionnaire) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Oral cryotherapy (ice chips, ice-cold water, ice cubes or crushed ice held in the mouth during cancer treatment) vs no intervention or control intervention (control)

Number of days of treatment with opioid analgesics · All patients with cancer who are receiving treatment

The review found no eligible studies for this question.

2 findings from 1 review