Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

153 questions · 160 findings · 33 reviews

No studies found 30 · 18.8%GRADE not reported 17 · 10.6%Very low 30 · 18.8%Low 46 · 28.8%Moderate 23 · 14.4%High 14 · 8.8%

Fractional laser vs combined chemical peeling plus needling

Participant‐assessed adverse events (short‐term) N of participants with adverse events · people with acne scars

It is very uncertain whether fractional laser changes participant‐assessed adverse events (short‐term) N of participants… compared with combined chemical peeling plus needling (very low certainty).

1 finding from 1 review

Chemical peeling vs combined chemical peeling plus any active intervention

Participant‐reported scar improvement (long‐term) · people with acne scars

It is very uncertain whether chemical peeling changes participant‐reported scar improvement (long‐term) N of participants… compared with combined chemical peeling plus any active intervention (very low certainty).

1 finding from 1 review

Chemical peeling vs combined chemical peeling plus any active intervention

Participant‐assessed adverse events (short‐term) N of participants with adverse events · people with acne scars

It is very uncertain whether chemical peeling changes participant‐assessed adverse events (short‐term) N of participants… compared with combined chemical peeling plus any active intervention (very low certainty).

1 finding from 1 review

Betaine (BET) toothpaste (4%) vs SLS toothpaste (1%) and combined BET+SLS toothpaste

Xerostomia (relief of oral dryness) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review
  • Rantanen 2003 (crossover): relief of oral dryness BET 44% vs BET+SLS 22% (P = 0.002) vs SLS 18% (P = 0.022) vs reference toothpaste 7% (P < 0.001); betaine-only significantly better than the other toothpastes. No…
    1 study
    GRADE not reported