Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

292 questions · 304 findings · 22 reviews

No studies found 72 · 23.7%GRADE not reported 48 · 15.8%Very low 61 · 20.1%Low 94 · 30.9%Moderate 29 · 9.5%High 0 · 0%

WENDAN DECOCTION vs placebo or no treatment

Global state: Clinically important change ‐ no improvement ‐ defined as PANSS < 50% reduction (short term) · patients with schizophrenia

WENDAN DECOCTION may leads to lower global state: Clinically important change ‐ no improvement ‐ defined… compared with PLACEBO OR NO TREATMENT (low certainty).

1 finding from 1 review

WENDAN DECOCTION vs antipsychotics

Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · patients with schizophrenia

WENDAN DECOCTION probably leads to lower adverse effects: Movement disorders ‐ Extra Pyramidal Symptoms… compared with ANTIPSYCHOTIC DRUG (moderate certainty).

1 finding from 1 review

WENDAN DECOCTION PLUS NORMAL DOSE ANTIPSYCHOTIC vs STANDARD DOSE ANTIPSYCHOTICS

Global state: Clinically important change ‐ no improvement ‐ defined as PANSS < 50% reduction (short term) · patients with schizophrenia

WENDAN DECOCTION PLUS NORMAL DOSE ANTIPSYCHOTIC probably leads to lower global state: Clinically important change ‐ no improvement ‐ defined… compared with NORMAL DOSE ANTIPSYCHOTIC (moderate certainty).

1 finding from 1 review

WENDAN DECOCTION PLUS NORMAL DOSE ANTIPSYCHOTIC vs STANDARD DOSE ANTIPSYCHOTICS

Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · patients with schizophrenia

WENDAN DECOCTION PLUS NORMAL DOSE ANTIPSYCHOTIC probably leads to lower adverse effects: Movement disorders ‐ Extra Pyramidal Symptoms… compared with NORMAL DOSE ANTIPSYCHOTIC (moderate certainty).

1 finding from 1 review

WENDAN DECOCTION PLUS NORMAL DOSE ANTIPSYCHOTIC vs STANDARD DOSE ANTIPSYCHOTICS

Adverse effects: Metabolic ‐ weight change (medium term) · patients with schizophrenia

WENDAN DECOCTION PLUS NORMAL DOSE ANTIPSYCHOTIC showed no clear difference in adverse effects: Metabolic ‐ weight change (medium term) compared with NORMAL DOSE ANTIPSYCHOTIC (low certainty).

1 finding from 1 review

WENDAN DECOCTION PLUS LOW DOSE ANTIPSYCHOTIC vs STANDARD DOSE ANTIPSYCHOTICS

Global state: Clinically important change ‐ no improvement ‐ defined as PANSS < 50% reduction (short term) · patients with schizophrenia

WENDAN DECOCTION PLUS LOW DOSE ANTIPSYCHOTIC probably leads to lower global state: Clinically important change ‐ no improvement ‐ defined… compared with NORMAL DOSE ANTIPSYCHOTIC (moderate certainty).

1 finding from 1 review

WENDAN DECOCTION PLUS LOW DOSE ANTIPSYCHOTIC vs STANDARD DOSE ANTIPSYCHOTICS

Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · patients with schizophrenia

WENDAN DECOCTION PLUS LOW DOSE ANTIPSYCHOTIC probably leads to lower adverse effects: Movement disorders ‐ Extra Pyramidal Symptoms… compared with NORMAL DOSE ANTIPSYCHOTIC (moderate certainty).

1 finding from 1 review