Overall success (composite of clinical and radiographic success) · Immature (young) permanent teeth with open apex and vital pulp exposed to dental caries or trauma, in children aged 6-14 years
A single RCT found no difference in pulpotomy success between MTA and calcium-enriched mixture (both 100% at 6 and 12 months; not pooled; ungraded).
1 finding from 1 review
Single RCT (Nosrat 2012, 118 roots): 100% clinical and radiographic success in both MTA and CEM at 6 and 12 months (MTA 53/53 then 54/54 roots; CEM 55/55 then 57/57 roots); no statistical difference between groups at…
1 study · 118 participants
GRADE not reported
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
Biodentine showed no clear difference in clinical failure compared with calcium hydroxide (CH); GRADE not reported.
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
Mineral trioxide aggregate (MTA) may leads to lower radiological failure compared with calcium hydroxide (CH) (low certainty).
2 findings from 1 review
RR 0.12 [0.04, 0.36]
4 studies · 150 participants
Low
No radiological failure in any participant; not estimable
1 study · 50 participants
GRADE not reported
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
It is very uncertain whether total-etching 36% phosphoric acid + acetone-based total-etch adhesive changes clinical failure compared with calcium hydroxide (CH) (very low certainty).
1 finding from 1 review
Enamel matrix derivative (EMD) vs Calcium hydroxide (CH)
Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
Mineral trioxide aggregate (MTA) + sodium hypochlorite (NaOCl) showed no clear difference in radiological failure compared with calcium hydroxide + sodium hypochlorite (NaOCl); GRADE not reported.
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
It is very uncertain whether self-etch adhesive + acetone-based total-etch adhesive changes radiological failure compared with calcium hydroxide (CH) (very low certainty).
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
It is very uncertain whether non-rinse conditioner + acetone-based total-etch adhesive changes radiological failure compared with calcium hydroxide (CH) (very low certainty).
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
It is very uncertain whether total-etching 36% phosphoric acid + acetone-based total-etch adhesive changes radiological failure compared with calcium hydroxide (CH) (very low certainty).
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
Low-level laser therapy (LLLT) showed no clear difference in radiological failure compared with low-level laser therapy (LLLT) + calcium hydroxide; GRADE not reported.
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
Mineral trioxide aggregate (MTA) probably leads to lower clinical failure compared with calcium hydroxide (CH) (moderate certainty).
2 findings from 1 review
RR 0.16 [0.04, 0.70]
4 studies · 150 participants
Moderate
No clinical failure in any participant (Tuna 2008); not estimable (direct pulp capping)
1 study · 50 participants
GRADE not reported
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
Zinc oxide and eugenol (ZOE) led to lower clinical failure compared with ZOE + calcium hydroxide + iodoform (unnamed product); GRADE not reported.
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
Low-level laser therapy (LLLT) showed no clear difference in radiological failure compared with calcium hydroxide (CH); GRADE not reported.
1 finding from 1 review
Formocresol (FC) pulpotomy vs Calcium hydroxide pulpectomy
Outcome not reported · Children with extensive decay involving the dental pulp in primary teeth
The review found no eligible studies for this question.
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
Erbium:YAG laser showed no clear difference in clinical failure compared with calcium hydroxide (CH); GRADE not reported.
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
Erbium:YAG laser led to lower radiological failure compared with calcium hydroxide (CH); GRADE not reported.
1 finding from 1 review