Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,352 questions · 1,400 findings · 169 reviews

No studies found 309 · 22.1%GRADE not reported 115 · 8.2%Very low 350 · 25%Low 324 · 23.1%Moderate 240 · 17.1%High 62 · 4.4%

Antibiotics vs placebo

Resolution of purulent secretion · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging

Antibiotics leads to higher severity or duration of different clinical symptoms: resolution of… compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Side effects – overall · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging

Antibiotics leads to higher side effects: total compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Interventions side effects: diarrhoea · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging

Antibiotics leads to higher side effects: diarrhoea compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Clinical failure · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging

Antibiotics leads to lower clinical failure compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Treatment failure within 4 weeks ‐ current drugs only ‐ inpatient · exacerbations of COPD

Antibiotics showed no clear difference in treatment failure within 4 weeks ‐ current drugs only ‐ inpatient compared with placebo (moderate certainty).

1 finding from 1 review