Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

203 questions · 265 findings · 15 reviews

No studies found 69 · 26%GRADE not reported 116 · 43.8%Very low 50 · 18.9%Low 24 · 9.1%Moderate 6 · 2.3%High 0 · 0%

Doxycycline + SRP vs Amoxicillin + metronidazole + SRP

Adverse events · Adults with aggressive periodontitis

Doxycycline + SRP showed no clear difference in adverse events compared with amoxicillin + metronidazole + SRP; GRADE not reported.

1 finding from 1 review

Tetracycline + SRP vs SRP

Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis

The review found no eligible studies for this question.

2 findings from 1 review

Intervention not reported

Aggression OAS, OAS‐M, MOAS, self‐reported incidents, CPRS subscale (endpoints fall between 2 weeks and 6 months) · Any individual experiencing recurrent aggressive outbursts or episodes
1 finding from 1 review

Intervention not reported

Impulsivity Q‐sort, Porteus Maze Test (endpoints fall between 2 weeks and 6 months) · Any individual experiencing recurrent aggressive outbursts or episodes
1 finding from 1 review

Intervention not reported

Hostility BPRS hostility sub scale, CPRS hostility subscale, Q‐sort, speech content analysis (endpoints fall between 1 and 6 months) · Any individual experiencing recurrent aggressive outbursts or episodes
1 finding from 1 review

Intervention not reported

Anger Self‐reported outbursts, Rosenweig Picture Frustration Test (endpoints fall between 2 weeks and 6 months) · Any individual experiencing recurrent aggressive outbursts or episodes
1 finding from 1 review