Findings

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Evidence found and GRADE certainty

4,749 questions · 14,261 findings · 832 reviews

No studies found 3,655 · 25.6%GRADE not reported 2,111 · 14.8%Very low 3,646 · 25.6%Low 3,028 · 21.2%Moderate 1,501 · 10.5%High 320 · 2.2%

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Intralesional triamcinolone vs Intralesional triamcinolone plus salvianolic acid B

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether intralesional triamcinolone changes maximal mouth opening (interincisal distance) compared with intralesional triamcinolone plus salvianolic acid B (very low certainty).

1 finding from 1 review

Intralesional dexamethasone injections vs placebo injection

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether intralesional dexamethasone injections changes maximal mouth opening (interincisal distance) compared with placebo injections (very low certainty).

2 findings from 1 review

Surgery plus Heister jaw opener vs Surgery plus wooden tongue depressors

Burning sensation (VAS 0-100) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
  • Vadepally 2019 measured burning sensation on a VAS but did not fully report results, stating there was no significant difference between the 2 groups (p=0.617).
    1 study · 50 participants
    GRADE not reported

Oxitard (antioxidant) vs Topical aloe vera gel

Difficulty in speech (participant-reported proxy) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Oxitard (antioxidant) led to lower difficulty in speech (participant-reported proxy) compared with aloe vera gel; GRADE not reported.

1 finding from 1 review

Abdominal dermal fat graft vs Nasolabial flap

Adverse effects · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
  • Kania 2022 reported 3/30 serious adverse effects (graft failure) requiring prolonged hospital stay in the abdominal dermal fat graft group; no GRADE rating.
    1 study · 30 participants
    GRADE not reported

Occlusal splint vs No treatment or placebo (non-occlusal or transparent-foil placebo splint)

Frequency of joint noise · People with temporomandibular disorders (TMD)

It is very uncertain whether occlusal splint changes frequency of joint noise compared with no treatment or placebo (non-occlusal or transparent-foil placebo… (very low certainty).

1 finding from 1 review

Pentoxifylline vs Placebo or no active treatment

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether pentoxifylline changes maximal mouth opening (interincisal distance) compared with placebo or no active treatment (very low certainty).

2 findings from 1 review

Hospital‐only intervention vs intervention that continues after hospital discharge

Pharmacotherapy + behavioural support vs neither · smoking cessation in hospitalised patients

Hospital‐only intervention leads to higher pharmacotherapy + behavioural support vs neither compared with intervention that continues after hospital discharge (high certainty).

1 finding from 1 review

Telephone quitline referral vs usual care or no treatment

Health system telephone counselling vs quitline · smoking cessation in hospitalised patients

It is very uncertain whether telephone quitline referral changes health system telephone counselling vs quitline compared with no treatment or usual care (very low certainty).

1 finding from 1 review

Pharmacotherapy plus counselling vs no pharmacotherapy or placebo plus counselling

Quit at longest · smoking cessation in hospitalised patients

Pharmacotherapy plus counselling leads to higher quit at longest compared with no pharmacotherapy or placebo plus counselling (high certainty).

3 findings from 1 review

Hospital‐only intervention vs intervention that continues after hospital discharge

Behavioural support ‐ asynchronous** · smoking cessation in hospitalised patients

It is very uncertain whether hospital‐only intervention changes behavioural support ‐ asynchronous** compared with intervention that continues after hospital discharge (very low certainty).

1 finding from 1 review

Hospital‐only intervention vs intervention that continues after hospital discharge

Behavioural support ‐ synchronous** · smoking cessation in hospitalised patients

Hospital‐only intervention showed no clear difference in behavioural support ‐ synchronous** compared with intervention that continues after hospital discharge (low certainty).

1 finding from 1 review

Summary of findings table ‐ Energy, protein and micronutrients vs standard diet

Incidence of pressure ulcers · inpatients who are mildly or seriously malnourished or at risk of being malnourished, elderly patients at risk of developing pressure ulcers

Summary of findings table ‐ Energy, protein and micronutrients showed no clear difference in incidence of pressure ulcers compared with standard diet (low certainty).

1 finding from 1 review

Summary of findings table ‐ Protein vs standard diet

Gastrointestinal adverse events · patients (> 65 years) following hip fracture; patients with a recent stroke

It is very uncertain whether summary of findings table ‐ Protein changes side effects: at least one adverse gastrointestinal event compared with standard diet (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Energy, protein and micronutrients vs standard diet

The proportion of pressure ulcers healed · long‐term care patients; inpatients without dehydration with energy intake by tube feeding; patients with pressure ulcers

Summary of findings table ‐ Energy, protein and micronutrients may leads to higher pressure ulcers healed compared with standard diet (low certainty).

1 finding from 1 review