Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,805 questions · 2,912 findings · 307 reviews · Headline outcomes only

No studies found 706 · 24.2%GRADE not reported 133 · 4.6%Very low 786 · 27%Low 696 · 23.9%Moderate 474 · 16.3%High 117 · 4%

Posterior reconstruction vs no posterior reconstruction

Urinary continence 12 months after surgery MCID: 5% absolute difference · men (ages > 18 years) with clinically localized prostate cancer

Posterior reconstruction showed no clear difference in urinary continence 12 months after surgery MCID: 5% absolute… compared with no posterior reconstruction (low certainty).

1 finding from 1 review

Posterior reconstruction vs no posterior reconstruction

Potency 12 months after surgery MCID: 5% absolute difference · men (ages > 18 years) with clinically localized prostate cancer

It is very uncertain whether posterior reconstruction changes potency recovery 12 months after surgery MCID: 5% absolute difference compared with no posterior reconstruction (very low certainty).

1 finding from 1 review

Posterior reconstruction vs no posterior reconstruction

Positive surgical margins MCID: 5% absolute difference · men (ages > 18 years) with clinically localized prostate cancer

Posterior reconstruction showed no clear difference in positive surgical margins MCID: 5% absolute difference compared with no posterior reconstruction (low certainty).

1 finding from 1 review

Pneumococcal conjugate vaccine vs control vaccine

CRM197‐PCV7in low‐risk infants OMPC‐PCV7in low‐risk infants PHiD‐PC10 and PHiD‐PC11 in low‐risk infants CRM197‐PCV7/9 and CRM197‐PCV7 plus TIVin older children · infants (predominantly < 6 months of age) and older children (aged 1 to 7 years)
1 finding from 1 review

Ketogenic diet (KD) vs usual care

Seizure freedom · children (aged 1 to 18 years) with drug‐resistant epilepsy

It is very uncertain whether ketogenic diet (KD) changes seizure freedom (100% reduction in seizure frequency) compared with usual care (very low certainty).

1 finding from 1 review

Ketogenic diet (KD) vs usual care

Treatment withdrawal · adults (aged 16 years and over) with drug‐resistant epilepsy

It is very uncertain whether ketogenic diet (KD) changes treatment withdrawal compared with usual care (very low certainty).

1 finding from 1 review