Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,584 questions · 3,695 findings · 567 reviews

No studies found 784 · 21.2%GRADE not reported 308 · 8.3%Very low 1,036 · 28%Low 971 · 26.3%Moderate 440 · 11.9%High 156 · 4.2%

Oestrogen + other treatments vs placebo

Incontinence not improved (generic inverse variance) (women's observation) ‐ oestrogen + other treatments versus placebo · patients with urinary incontinence in post‐menopausal women

Oestrogen + other treatments probably leads to higher incontinence not improved (generic inverse variance) (women's… compared with placebo (moderate certainty).

1 finding from 1 review

Oestrogen vs placebo or no treatment

Incontinence not improved (generic inverse variance) (women's observations) ‐ Local administration (any incontinence) · patients with urinary incontinence in post‐menopausal women

It is very uncertain whether oestrogen changes incontinence not improved (generic inverse variance) (women's… compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Uncemented fixation with and without hydroxyapatite vs cemented fixation

Arthroplasty instability ‐ inferred from roentgen stereophotogrammetric analysis (Available data analysis) · Patients with osteoarthritis and other non‐traumatic diseases

Uncemented fixation with and without hydroxyapatite probably leads to lower arthroplasty instability ‐ inferred from roentgen… compared with cemented fixation (moderate certainty).

1 finding from 1 review

Intervention not reported

Left ventricular ejection fraction decline (LVEF) · HER2‐positive early breast cancer patients

The intervention probably leads to higher left ventricular ejection fraction decline (LVEF) (moderate certainty).

1 finding from 1 review

Febuxostat 120 mg/day vs placebo

Serum uric acid <6.0 mg/dL at final visit · patients with chronic cout

Febuxostat 120 mg/day may leads to higher serum uric acid <6.0 mg/dL at final visit compared with placebo (low certainty).

1 finding from 1 review

Febuxostat 40 mg/day vs placebo

Serum uric acid <6.0 mg/dL at final visit · people with chronic gout

Febuxostat 40 mg/day may leads to higher serum uric acid <6.0 mg/dL at final visit compared with placebo (low certainty).

1 finding from 1 review

Febuxostat 40 mg/day vs allopurinol

Serum uric acid <6.0 mg/dL at final visit · people with chronic gout

Febuxostat 40 mg/day showed no clear difference in serum uric acid <6.0 mg/dL at final visit compared with allopurinol (moderate certainty).

1 finding from 1 review

Febuxostat 80 mg/day vs allopurinol

Serum uric acid <6.0 mg/dL at final visit · people with chronic gout

Febuxostat 80 mg/day may leads to higher serum uric acid <6.0 mg/dL at final visit compared with allopurinol (low certainty).

1 finding from 1 review

Febuxostat 120 mg/day vs allopurinol

Serum uric acid <6.0 mg/dL at final visit · people with chronic gout

Febuxostat 120 mg/day probably leads to higher serum uric acid <6.0 mg/dL at final visit compared with allopurinol (moderate certainty).

1 finding from 1 review

Febuxostat 80 mg/day vs placebo

Serum uric acid <6.0 mg/dL at final visit · people with chronic gout

Febuxostat 80 mg/day may leads to higher serum uric acid <6.0 mg/dL at final visit compared with placebo (low certainty).

1 finding from 1 review

Intervention not reported

Utilisation of research (Thailand) (for six obstetric practices: social support during labour, magnesium sulphate for eclampsia, corticosteroids to women with preterm birth, selective episiotomy, antibiotic use at caesarean section and vacuum extr... · Healthcare decision makers, health system managers or policy makers
1 finding from 1 review

Intervention not reported

Utilisation of research (Mexico) (for six obstetric practices: social support during labour, magnesium sulphate for eclampsia, corticosteroids to women with preterm birth, selective episiotomy, antibiotic use at caesarean section and vacuum extrac... · Healthcare decision makers, health system managers or policy makers
1 finding from 1 review

Intervention not reported

Utilisation of research (4 obstetric practices: use of polyglycolic acid sutures, ventouse for instrumental delivery, prophylactic antibiotics in caesarean section, and prophylactic corticosteroids in preterm deliveries).2 · Healthcare decision makers, health system managers or policy makers
1 finding from 1 review